CRP及D-Dimer在慢性阻塞性肺疾病急性加重期继发肺动脉高压中的相关性  

Association of CRP and D-Dimer with secondary pulmonary hypertension in patients with AECOPD

作　　者：金丛 黄相增[1] 

机构地区：[1]新疆医科大学第二附属医院呼吸内科,乌鲁木齐市830054

出　　处：《实用医学杂志》2014年第24期3949-3951,共3页The Journal of Practical Medicine

摘　　要：目的:探讨C反应蛋白(CRP)及D-二聚体(D-Dimer)在慢性阻塞性肺疾病急性加重期(AECOPD)合并肺动脉高压(PH)患者中的临床意义及相关性。方法:150例AECOPD患者进行CRP、D-Dimer及动脉血气检测。结果:AECOPD合并中重度PH组患者CRP、D-Dimer、Pa CO2水平高于轻度PH组及对照组,(P<0.05),而Pa O2水平低于轻度PH组及对照组(P<0.05)。AECOPD合并轻度PH组患者CRP、D-Dimer水平高于对照组(P<0.05)。CRP、D-Dimer、Pa CO2与肺动脉收缩压(PASP)呈正相关;Pa O2与PASP呈负相关;CRP、D-Dimer与Pa CO2呈正相关;CRP、D-Dimer与Pa O2呈负相关。结论:CRP及D-Dimer水平可作为AECOPD患者判断PH严重程度的指标。Objective To explore the clinical significance of C-reaction protein （CRP） and D-Eimer levels in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） complicate t by pulmonary hypertension （PH） and their association with HP. Methods Arterial blood gas and levels of CRY and D-Dimer were detected in 150 patients with AECOPD. Results Levels of CRP, D-Dimer, and PaCO2 were higher but PO2 level was lower in patients with moderate to severe PH than those with mild PH and the control subjects. Levels of CRP and D-Dimer were higher in patients with mild PH than the control subjects. Levels of （RP, D-Dimer, and PCO2 levels had a linear relationship with PASP, while PO2 was negatively correlated with P^SP. Levels of CRP and D-Dimer were positively related with PCO2, while were negatively correlated with PO2. Conclusions Levels of CRP and D-Dimer can be used as an indicator for estimating the severity of pulm, mary hypertension in patients with AECOPD.

关 键 词：慢性阻塞性肺疾病 肺动脉高压 C反应蛋白 D-二聚体 

分 类 号：R563.9[医药卫生—呼吸系统]