黄体酮联合调经活血片治疗抗精神病药物所致的药源性闭经的疗效观察  

Efficacy of progesterone combined with Tiaojinghuoxue tablets treatment of amenorrhea induced by antipsychotic drugs

作　　者：邱璐 李琼[2] 朱丹[2] 

机构地区：[1]广西南宁市第五人民医院妇产科,530001 [2]广西医科大学药学院,南宁市530021

出　　处：《实用医学杂志》2014年第24期4018-4020,共3页The Journal of Practical Medicine

基　　金：广西自然科学基金(编号:2013GXNSFBA019150)

摘　　要：目的:探讨黄体酮联合调经活血片治疗抗精神病药物所致的药源性闭经的临床疗效与安全性。方法:将100例抗精神病药物所致的药源性闭经的患者随机分为黄体酮组和黄体酮联合调经活血片组各50例,分别予黄体酮和黄体酮联合调经活血片治疗。于治疗前后分别测定两组的催乳素(PRL)、促黄体生成素(LH)、雌二醇(E2)、子宫内膜厚度,并比较两组的临床疗效。结果 :联合用药组的PRL、LH、E2和子宫内膜厚度恢复情况以及月经量评分均优于黄体酮组,差异有统计学意义(P<0.05或P<0.01);联合用药组的治愈率(74.00%)与对照组(54.00%)差异有统计学意义(P<0.05),联合组总有效率(90.00%)与对照组(80.00%)差异无统计学意义(P>0.05);联合用药组不良反应发生率(22.00%)明显少于黄体酮组(40.00%),差异有统计学意义(P<0.05)。结论:黄体酮联合调经活血片抗精神病药物所致的药源性闭经的疗效优于单用黄体酮治疗,不良反应少。Objective To explore the clinical efficacy and safety of progesterone combined with Tiaojinghuoxue tablets in treating amenorrhea induced by antipsychotic drugs. Methods Total 100 patients were randomly divided into treatment group treated by progesterone combined with Tiaojinghuoxue tablets and progesterone group. The index including prolactin （PRL）, luteinizing hormone （LH）, estradiol （E2）, endometrial thickness were measured before and after treatment in both groups. Also the clinical efficacy of the twogroups were compared. Results PRL, LH, E2, endometrial thickness and the recovery of menstrual flow rates in combination group were all better than the progesterone group, （P 〈 0.05 or P 〈 0.01 ）. Cure rate in the combined group was 54.00% and the control group was 74.00% （P 〈 0.05）. Total effective rate of combined group was 90.00% and the control group was 80.00% （P 〉 0.05 ）. The rate of adverse reactions in combined group was 40.00%, less than 22.00% in progesterone group, （P 〈 0.05）. Conehmion The efficacy of progesterone combined withTiaojinghuoxue tablets is better than single progesterone treatment and have fewer adverse reactions in therpy antipsychotics drug induced amenorrhea.

关 键 词：药物性闭经 调经活血片 黄体酮 抗精神病药物 血催乳素 

分 类 号：R711.51[医药卫生—妇产科学]