高血压大鼠阴茎白膜弹性纤维改变对勃起功能影响的研究  

The research on changes of elastic fiber in penis tunica albuginea in hypertensive rats on erectile function

作　　者：程祎 吴威武 李杰 叶朝阳 黎明 

机构地区：[1]东莞市第五人民医院泌尿外科,广东省523900

出　　处：《中华临床医师杂志（电子版）》2014年第24期96-98,共3页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的了解高血压大鼠白膜中弹性纤维改变对勃起功能的影响。方法选择16周龄雄性自发性高血压大鼠(SHR)20只和同系正常血压大鼠(WKY)10只,利用阿扑吗啡诱导勃起试验,将大鼠分为高血压勃起功能障碍组(SHR-ED)、高血压组(SHR)及正常对照组(Control),利用维多利亚蓝-丽春红染色法对不同处理组的阴茎海绵体标本进行弹性纤维的染色,利用彩色图文系统进行分析,以累积光密度(IOD)作为测量指标。结果 SHR大鼠死亡2只,余下SHR-ED组11只,SHR组7只,Control组10只。各处理组间阴茎白膜弹性纤维存在统计学差异(F=79.024,P=0.000),SHR-ED组阴茎白膜弹性纤维IOD含量少于SHR组(P=0.000),SHR组阴茎白膜弹性纤维IOD含量小于Control组(P=0.000)。结论高血压可以导致白膜弹性纤维的减少,高血压大鼠白膜弹性纤维减少到一定程度将导致勃起功能障碍。Objective To investigate the changes of elastic fiber in penis tunica albuginea in hypertensive rats on erectile function. Methods 20 16-week-old male spontaneously hypertensive rats（SHR） and 10 syngeneic normotensive rats（WKY） were used. After examination of the erectile function with subcutaneous injection of apomorphine（APO）, the rats were divided into 3 groups, namely hypertensive with erectile dysfunction（SHR-ED） and control group. Victoria blue/Ponceau red staining and color image analysis were used to observe the content of elastic fiber in tunica albuginea. Results There were 2 SHR rats died, 11 rats were divided into SHR-ED group, 7 in TO SHR group and 10 rats in control group. The expression of elastic fiber in penis tunica albuginea exists significant difference between different test group（F=79.024, P=0.000）. The content of elastic fiber in tunica albuginea in SHR-ED group is lower than SHR group（P=0.000）, while the content of elastic fiber in tunica albuginea in SHR group is lower than control group（P=0.000）. Conclusion Decrease of elastic fiber in tunica albuginea can result from hypertensive disease. Erectile dysfunction can be caused by the elastic fiber reduced to a certain degree in tunica albuginea.

关 键 词：高血压 勃起功能障碍 阴茎 白膜 弹性纤维 大鼠 

分 类 号：R544.1[医药卫生—心血管疾病]