温阳方治疗慢性心力衰竭的临床研究  

Clinical study of Wenyangfang in the treatment of heart failure

作　　者：马彩艳[1] 童鸿[1] 谢培怡[1] 李小玲[1] 叶建华[1] 

机构地区：[1]浙江省立同德医院心内科,杭州310012

出　　处：《中国临床药理学杂志》2015年第1期5-7,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省中医药科技计划基金资助项目(2010B541470)

摘　　要：目的探讨温阳方联合西药治疗慢性心力衰竭(CHF)的临床疗效。方法70例CHF患者随机分温阳方+西药治疗组35例(试验组)和西药治疗组35例(对照组)。对照组给予降血压、β受体阻滞剂、利尿剂、强心等药物治疗;试验组在对照组的基础上予以温阳方,2组患者治疗1个月。治疗1个月后评价2组患者神经内分泌指标及左室射血分数(LVEF)。结果治疗1个月后,试验组与对照组血浆去甲肾上腺素(NE)、血管紧张素Ⅱ(AngⅡ)和醛固醇(ALD)均明显降低(P<0.05),左室射血分数(LVEF)均显著升高(P<0.05),但试验组与对照组相比变化更为显著(P<0.05)。治疗后试验组总有效率显著高于对照组(P<0.05)。结论温阳方联合西药治疗CHF可显著提高LVEF,改善心力衰竭症状。Objective To evaluate the clinical effects of Wenyang in the treatment of chronic heart failure（ CHF）.Methods Seventy patients with CHF were recruited and randomly divided into experiment group（ n = 35） and control group（ n = 35）.Patients in the experiment group were treated with Wenyangfang and west medicine; patients in the control group were treated with west medicine only.All the patients were treated1 month.After 1 month treatment,the neuroendocrine indicators and LVEF were compared between the two groups.Results After treatment of 1 month,the norepinephrine,angiotensin Ⅱ（ Ang Ⅱ）,aldosterone（ ALD） were decreased in both experiment and control group（ P〈0.05）,the left ventricular ejection fraction（ LVEF） was both improved in the two groups.And the experiment group was much significant than that of control group（ P〈0.05）.The total efficacy in the experiment group was much higher than that of control group（ P〈0.05）.Conclusion Wenyangfang combined with the medicine can significant improve the LVEF and symptom in patients with CHF.

关 键 词：温阳方 慢性心力衰竭 Β受体阻滞剂 临床疗效 

分 类 号：R932[医药卫生—生药学] R541.6[医药卫生—药学]