美罗培南临床治疗早产儿重症细菌感染的疗效分析  

Clinical efficacy of meropenem in treatment of severe bacterial infections in premature infants

作　　者：顾海红 黄烈平 王吉 

机构地区：[1]舟山市妇幼保健院新生儿科,浙江舟山316000

出　　处：《中华医院感染学杂志》2015年第1期85-86,107,共3页Chinese Journal of Nosocomiology

基　　金：浙江省医药科技基金资助项目(2011RCB037)

摘　　要：目的探讨美罗培南治疗早产儿重症细菌感染的临床疗效,为治疗早产儿重症细菌感染提供可行性药物治疗方案。方法选取舟山市妇幼保健院新生儿科2011年1月-2013年12月124例早产重症细菌感染患儿为研究对象,按照患儿入院先后顺序分为美罗培南组和头孢噻肟组,各62例,头孢噻肟组患儿给予头孢噻肟针剂进行静脉滴注治疗,美罗培南组患儿给予美罗培南静脉滴注治疗,观察两组治疗效果及细菌清除率,采用SPSS13.0软件进行统计分析。结果美罗培南组痊愈率67.74%、总有效率96.77%、细菌清除总有效率84.38%,头孢噻肟组分别为45.16%、87.10%、67.86%,两组比较差异有统计学意义(P<0.05);两组不良反应差异无统计学意义。结论美罗培南临床治疗早产重症细菌感染患儿,能有效清除病原菌,改善患儿临床症状,提高治疗效果,建议临床推广应用。OBJECTIVE To explore the clinical efficacy of meropenem in treatment of the premature infants with se-vere bacterial infections so as to provide feasible drug therapy program for the treatment of the premature infants with severe bacterial infections.METHODS A total of 124 premature infants with severe bacterial infections,who were treated in the neonatal departments of Maternal and Child Health Hospital of Zhoushan from Jan 2011 to Dec 2013,were recruited as the study objects and divided into the meropenem group and the cefotaxime group accord-ing to the order of admission to the hospital,with 62 cases in each;the meropenem group was treated with mero-penem,and the cefotaxime group was given cefotaxime;the therapeutic effect and the bacterial clearance rate were observed and compared between the two groups,and the statistical analysis was performed by using SPSS13.0 software.RESULTS The cure rate was 67.74% in the meropenem group,45.16% in the cefotaxime group;the to-tal effective rate was 96.77% in the meropenem group,87.10% in the cefotaxime group;the total effective rate of bacterial clearance was 84.38% in the meropenem group,67.86% in the cefotaxime group,there were significant differences between the two groups （P〈0.05）;there was no significant difference in the incidence of adverse re-actions between the two groups.CONCLUSION For the clinical treatment of the premature infants with severe bac-terial infections,meropenem can effectively eradicate pathogens,improve the clinical symptoms,and raise the therapeutic effect,it is worthy to be promoted in the hospital.

关 键 词：早产儿 重症细菌感染 美罗培南 

分 类 号：R978.1[医药卫生—药品]