盐酸氨溴索联合不同药物治疗老年急性肺炎疗效探讨  

Study on the effect of Ambroxol hydroehloride combined with different kinds of drugs in the treatment of senile acute pneumonia

作　　者：张金彭[1] 吴玉泉[1] 周春[1] 费明峰[1] 卢小军[1] 陈清勇[2] 

机构地区：[1]解放军第一一七医院老年医学科,杭州310013 [2]解放军第一一七医院呼吸内科,杭州310013

出　　处：《国际医药卫生导报》2015年第2期230-233,共4页International Medicine and Health Guidance News

摘　　要：目的研究盐酸氨溴索联合不同药物治疗老年急性肺炎的临床疗效。方法选择2013年4月至2014年3月我院老年医学科和呼吸内科因急性肺炎住院的老年患者78例，随机分为观察组40例和对照组38例。对照组给予盐酸氨溴索联合左氧氟沙星治疗，观察组给予盐酸氨溴索联合头孢哌酮舒巴坦钠治疗。治疗1周后分析比较两组患者的治疗效果、不良反应发生率以及C－反应蛋白（CRP）、血清降钙素原（PCT）水平。结果观察组总有效率为90．00％，高于对照组的71．50％，差异有统计学意义（P〈0．05）;观察组PCT、CRP水平分别为（0．64±0．23）ng/ml、（29．58±8．62）pg／ml，均低于对照组，差异有统计学意义（P〈0．05）；观察组不良反应发生率与对照组比较差异无统计学意义（P〉0．05）。结论盐酸氨溴索联合头孢哌酮舒巴坦钠治疗老年急性肺炎疗效显著，减轻了患者炎症反应，不良反应轻微，值得临床重视。Objective To research clinical effect of Ambroxol hydrochloride combined with different kinds of drugs in the treatment of senile acute pneumonia. Methods 78 elderly patients with acute pneumonia in department of geriatrics and respiratory department of internal medicine of our hospital from April 2013 to March 2014 were selected and randomly divided into observation group （40 cases） and control group （38 cases）. Control group was given Ambroxol hydrochloride combined with Levofloxacin, while observation group was given Ambroxol hydrochloride combined with Cefoperazone sulbactam sodium. Compared the therapeutic effect, the incidence of adverse reactions and C-reaction protein （CRP）, serum procalcitonin （PCT） of two groups a week after treatment. Results The total efficiency of observation group was 90.00%, higher than 71.50% of control group, with statistically significant difference （P 〈 0.05）. PCT, CRP level of observation group were （0.64 ±0.23） ng/ml, （29.58±8.62） pg/ml respectively, lower than those of control group, with statistically significant differences （P 〈 0.05）. There was no statistically significant difference in the incidence of adverse reactions between two groups （P 〉 0.05）. Conclusion Ambroxol hydrochloride combined with Cefoperazone sulbactam sodium in the treatment of senile acute pneumonia has significant effect, can reduce inflammatory responses in patients, with mild adverse reactions, worthy of clinical attention.

关 键 词：老年急性肺炎 盐酸氨溴索 头孢哌酮舒巴坦钠 疗效评价 

分 类 号：R974.1[医药卫生—药品]