3-O-脱克拉定糖-3-氧代-9-取代吖嗪克拉霉素衍生物的合成及抗菌活性  

Synthesis and Antibacterial Activities of 3-O-Decladinosyl-3-oxo-9-substituted Azine Clarithromycin Derivatives

作　　者：姚岚[1] 葛涵[1] 沈舜义[1] 

机构地区：[1]中国医药工业研究总院上海医药工业研究院,上海200040

出　　处：《中国医药工业杂志》2015年第1期13-16,共4页Chinese Journal of Pharmaceuticals

摘　　要：以克拉霉素为原料,设计并合成了12个3-O-脱克拉定糖-3-氧代-9-取代吖嗪克拉霉素衍生物。体外抗菌活性试验结果表明,它们对受试的革兰阳性菌,包括金葡菌、表皮葡萄球菌、白色葡萄球菌、肺炎双球菌和丙型链球菌均有良好的抗菌活性。Twelve new 3-O-decladinosyl-3-oxo-9-substituted azine clarithromycin derivatives were synthesized from clarithromycin. The antibacterial activities of the title compounds were tested in vitro and the results showed that these compounds exhibited good antibacterial activities against the tested gram-positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus albus, Diplococcus lanceolatus and Gamma streptococcus.

关 键 词：3-O-脱克拉定糖-3-氧代-9-取代吖嗪 克拉霉素衍生物 合成 抗菌活性 

分 类 号：R978.15[医药卫生—药品] O623.624[医药卫生—药学]