枸橼酸铁肠溶微囊的制备及评价  

Preparation and Evaluation of Ferric Citrate Enteric Microcapsules

作　　者：罗丽娟[1] 胡延春[1] 舒刚[1] 蓝岚 蒋忠荣 

机构地区：[1]四川农业大学动物医学院,四川雅安625014 [2]四川甘孜州畜牧科学研究所,四川康定626000

出　　处：《中国医药工业杂志》2015年第1期40-43,共4页Chinese Journal of Pharmaceuticals

基　　金：甘孜州重点科技攻关项目(2012201);四川农业大学校州合作项目(20132270)的资助

摘　　要：以丙烯酸树脂Ⅱ为囊材,采用乳化溶剂挥发法制备五水合枸橼酸铁肠溶微囊。以包封率为评价指标,通过响应面法优化制备工艺。优化后的处方为五水合枸橼酸铁0.26 g,液体石蜡160 ml,滑石粉0.32 g,Span-80 0.68 g。建立了火焰原子吸收光谱法测定微囊中铁元素含量。结果显示,优化所得的微囊表面光滑圆整,平均粒径为240μm,载药量21.5%,包封率94.1%,在pH 1.0盐酸中120min内溶出率低于10%,而在pH 6.8磷酸盐缓冲液中约80%。The enteric microcapsules loaded with five hydrated ferric citrate were prepared by emulsion solvent evaporation method with acrylic resin Ⅱ as coating material. The formulation was optimized by response surface methodology with encapsulation efficiency as the index. The optimal formulation was as follows： 0.26 g of five hydrated ferric citrate, 160 ml of liquid paraffin, 0.32 g of talcum powder and 0.68 g of Span-80. A flame atomic absorption spectrometry was established for the determination of iron in the microcapsules. The results showed that the optimal product was smooth and spherical with mean particle size of 240 jim. The drug loading and encapsulation efficiency were 21.5% and 94.1%. The dissolution within 120 min in hydrochloric acid （pH 1.0） of the product was less than 10% while in pH 6.8 phosphate buffer was about 80%.

关 键 词：枸橼酸铁 丙烯酸树脂Ⅱ 肠溶微囊 乳化溶剂挥发法 

分 类 号：R944.9[医药卫生—药剂学]