盐酸达泊西汀中甲磺酸甲酯、甲磺酸乙酯及甲磺酸异丙酯的顶空毛细管GC-ECD法测定  

Determination of Methyl,Ethyl and Isopropyl Methanesulfonate in Dapoxetine Hydrochloride by Headspace Capillary GC-ECD

作　　者：张萌萌[1] 潘红娟[1] 陈佳[1] 刘晓慧[1] 

机构地区：[1]中国医药工业研究总院上海医药工业研究院分析测试中心,上海200437

出　　处：《中国医药工业杂志》2015年第1期55-58,共4页Chinese Journal of Pharmaceuticals

摘　　要：建立了衍生化顶空毛细管气相色谱。电子捕获检测器（ECD）法测定盐酸达泊西汀中的甲磺酸甲酯（MMS）、甲磺酸乙酯（EMS）和甲磺酸异丙酯（IMS）。应用碘化钠衍生技术，使用PW-5毛细管柱，载气为氮气，ECD检测，程序升温。MMS、EMS和IMS分别在0．03～0．30、0．05～0．50和0．05～0．50gg／ml浓度范围内线性关系良好，平均回收率分别为63．5％、100-3％和96．2％，最低检测限分别为0．30、0．50和0．50ng／ml。A derivative headspace capillary GC method using electron capture detector （ECD） was established for the determination of methyl, ethyl and isopropyl methanesulfonate （MMS, EMS and IMS） in dapoxetine hydrochloride. A PW-5 capillary column was used, with sodium iodide as the iodonation agent, nitrogen as the carrier gas, and ECD as the detector in temperature program mode. The calibration curves for MMS, EMS and IMS were linear in the ranges of 0.03 - 0.30, 0.05 - 0.50 and 0.05 - 0.50μg/ml, respectively. Their average recoveries were 63.5 %, 100.3 % and 96.2 %, with LLODs of 0.30, 0.50 and 0.50 ng/ml, respectively.

关 键 词：盐酸达泊西汀 甲磺酸甲酯 甲磺酸乙酯 甲磺酸异丙酯 衍生化 顶空毛细管气相色谱 电子捕获检测器 测定 

分 类 号：R917[医药卫生—药物分析学]