非典型疯牛病研究进展  

Progress on Atypical Bovine Spongiform Encephalopathy

作　　者：刘雨田[1] 孙成友[1] 迟田英[1] 肖卫华 王志亮[1] 

机构地区：[1]中国动物卫生与流行病学中心,山东青岛266032 [2]江西省遂川县畜牧兽医局,江西遂川343906

出　　处：《动物医学进展》2015年第1期106-109,共4页Progress In Veterinary Medicine

基　　金：现代农业(奶牛)产业技术体系建设项目(CARS-37)

摘　　要：自2001年欧盟实施疯牛病主动监测以后,人们发现一种新的与典型疯牛病不一样的疯牛病,即非典型疯牛病。后来,在日本、加拿大、美国、巴西等也发现非典型疯牛病。目前普遍认为,该类疯牛病多发于老年牛,临床上有的表现症状,有的无症状,具有自发性和散发性特征,发病率低,约为百万分之一至百万分之三。研究发现,非典型疯牛病可以分为H型和L型,两者在PK酶抗性、糖基化、传染性、机体内分布等存在差异,同时与典型疯牛病也存在明显差异。比较来看,L型疯牛病的传染性最强,H型疯牛病的传染性较弱。论文从非典型疯牛病的临床症状、病理变化、病原分布及分子特性、传染性等方面做了详细介绍。Since the active surveillance of bovine spongiform encephalopathy （BSE） was implemented in EU in 2001,a new kind of BSE,namely atypical BSE,which was different from classical BSE was emerged. Subsequently,atypical BSEs were also found in Japan,Canada,America,Brazil,and so on.It is widely accepted that this kind of BSE was often observed within old cattle with or without clinical signs.The ap-parent incidence of atypical BSE was low,approximately 1-3 cases per million cattle.It was characterized by spontaneity and sporadicness.Experimental evidence showed that atypical BSE included H-type and L-type cases which were distinct from protease K resistant,glycosylation,transmission,agent distribution in vivo,and so on.Meanwhile,there was obvious difference between atypical and classical BSE.L-BSE had stronger transmissibility by comparison with H-BSE.This paper introduced clinic symptoms,patho-logical lesions,agent distribution,molecular feature,transmissibility of atypical BSE in detail.

关 键 词：非典型疯牛病 临床症状 病理变化 病原分子特性 传染性 

分 类 号：S852.659.7[农业科学—基础兽医学]