钯催化烯丙基磺酰胺的分子内胺氟化反应  

Pd-catalyzed intramolecular aminofluorination of allylic sulfamides

作　　者：程家顺 陈品红[1] 刘国生[1] 

机构地区：[1]中国科学院上海有机化学研究所金属有机国家重点实验室,上海200032

出　　处：《催化学报》2015年第1期40-47,共8页

基　　金：supported by the National Basic Research Program of China (973 program; 2011CB808700);the National Natural Science Foundation of China (21225210; 20923005 and 21121062);the Science and Technology Commission of Shanghai Municipality (11JC1415000);the CAS/SAFEA International Partnership Program for Creative Research Teams~~

摘　　要：报道了钯催化的非活性烯烃的胺氟化反应,在酸性添加剂HOAc的作用下,反应以较好的收率和区域选择性地得到6-endo环合产物,实现了氟代的环状磺胺类产物的有效合成.A facile Pd-catalyzed intramolecular aminofluorination reaction of allylic sulfamides was developed that can be used to prepare fluorinated 1,3-diamine derivatives. Acetic acid was essential for regula-tion to give the major 6-endo cyclization products.

关 键 词：钯催化 胺氟化 烯烃 氟代1 3-二胺 6-endo环合 

分 类 号：O643.32[理学—物理化学]