手性螺环双膦氧化物催化的不对称还原-Aldol反应(英文)  

Highly enantio- and diastereoselective reductive aldol reactions catalyzed by chiral spiro bisphosphine oxides

作　　者：张攀科[1] 刘家旺[1] 王正[1] 丁奎岭[1] 

机构地区：[1]中国科学院上海有机化学研究所金属有机国家重点实验室,上海200032

出　　处：《催化学报》2015年第1期100-105,共6页

基　　金：supported by the National Basic Research Program of China (2010CB833300);the National Natural Science Foundation of China (21121062, 21232009);the Chinese Academy of Sciences;the Science and Technology Commission of Shanghai Municipality~~

摘　　要：以螺环膦氧化合物为催化剂及三氯硅氢为还原剂,发展了手性Lewis碱催化的烯酮与醛的不对称还原-Aldol反应.该类催化剂在查耳酮以及类似物与各种醛的不对称还原-Aldol反应中表现出较高的反应活性和良好的立体选择性,以较好的产率(45%-88%)、中等到优秀的非对映选择性(8:92-100:0)以及最高达95%的ee值得到相应的还原Aldol产物.A spiro bisphosphine oxide（SpinP O） was found to be an efficient chiral Lewis base catalyst in asymmetric reductive aldol reaction of enones and aldehydes in the presence of trichlorosilane as the reductant, affording a variety of β-hydroxyketones in good yields with moderate to high levels of diastereo- and enantioselectivities.

关 键 词：醛 不对称催化 烯酮 路易斯碱 还原Aldol反应 螺环膦氧化合物 

分 类 号：O621.251[理学—有机化学]