初发2型糖尿病患者内脂素与铁代谢关系研究  

Relationship study of blood serum visfatin and iron metabolism in newly diagnosed type 2 diabetes mellitus

作　　者：孙雪[1] 张亚华[2] 徐淑静[3] 时立新[3] 彭年春[3] 张巧[3] 

机构地区：[1]湖北医药学院附属东风总医院内分泌科,湖北十堰442008 [2]贵阳医学院附属医院急诊内科,贵阳550004 [3]贵阳医学院附属医院内分泌科,贵阳550004

出　　处：《重庆医学》2015年第2期194-196,共3页Chongqing medicine

基　　金：贵州省科技厅社会发展科技攻关计划项目(黔科合LG字[2011]017号)

摘　　要：目的检测初发2型糖尿病患者血清内脂素及铁代谢相关指标血清铁蛋白、铁调素、可溶性转铁蛋白受体(sTfR)水平,探讨初发2型糖尿病患者血清内脂素与铁代谢之间的相关性。方法初发2型糖尿病患者85例,其中体质量正常者43例(正常体质量糖尿病组,B组),肥胖者42例(肥胖糖尿病组,D组);同期选取健康体检者86名,其中体质量正常者(对照组,A组)及肥胖者(单纯性肥胖组,C组)各43例,测定所有受试者血清内脂素和铁蛋白、铁调素、sTfR水平。结果 4组研究对象血清内脂素与铁代谢指标铁蛋白、铁调素、sTfR均无明显相关性(r=0.111,P>0.05)。结论初发2型糖尿病患者血清内脂素水平与铁代谢指标铁蛋白、铁调素、sTfR之间无相关性。Objective To determine the concentration of blood serum visfatin and some iron metabolism‐related indicators：Ser‐um ferritin、hepcidin、serum transferring receptor（sTfR）level in newly diagnosed type 2 diabetes patients and explore the inter‐rela‐tionship between blood serum visfatin and iron metabolism .Methods Eighty‐five patients with newly diagnosed type 2 diabetes mellitus were selected and divided into 2 groups including 43 patients with normal weight （the normal weight of diabetic group , group B）and 42 obese patients （the obese diabetic group ,group D） .Meanwhile ,86 healthy examinees were selected and divided into 2 groups including 43 cases with normal weight （the control group ,group A）and 43 cases with obese （simple obesity group ,group C） .Serum visfatin ,ferritin ,hepcidin ,serum transferring receptor level and other clinical parameters of all groups were determined . Results Blood serum visfatin concentration was not found to be associated with ferritin ,hepcidin ,serum transferring receptor in all the groups（r=0 .111 ,P〉0 .05） .Conclusion Blood serum visfatin may be not associated with ferritin ,hepcidin ,serum transferring receptor in newly diagnosed type 2 diabetes patients .

关 键 词：内脂素 铁蛋白 糖尿病  2型 铁调素 可溶性转铁蛋白受体 

分 类 号：R587.1[医药卫生—内分泌]