纤维基组织工程心脏瓣膜支架研究进展  

Study Progress of Fiber-Based Tissue-Engineered Heart Valve Scaffold

作　　者：赵帆[1,2] 王富军[1,2] 毛迎 王璐[1,2] 

机构地区：[1]东华大学纺织学院,上海201620 [2]东华大学纺织面料技术教育部重点实验室,上海201620

出　　处：《东华大学学报（自然科学版）》2014年第6期752-757,共6页Journal of Donghua University(Natural Science)

摘　　要：心脏瓣膜损坏或缺陷所导致的疾病已成为危害人类健康的主要疾病之一.由纤维材料成型技术制备的组织工程支架具有良好的可设计性和较好的力学和生物性能,逐渐成为组织工程心脏瓣膜支架的主要制备方法.全文重点介绍了纤维基组织工程心脏瓣膜支架的研究进展,对采用针织、非织造以及静电纺丝制备技术得到的微纳米纤维基支架的各自特点进行了对比分析,由此表明具有优良生物相容性和可控力学性能的三维多孔纳米纤维基支架将是组织工程心脏瓣膜支架的发展方向.The disease caused by heart valve damage or defect has become one of the major diseases which have threaten human health.The tissue-engineered scaffold prepared by fiber technology has good mechanical and biological properties,thus this technology gradually becomes the main method.This paper focused on the research progress of fiber-based tissue-engineered heart valve scaffold and compared the characteristics among different micro and nano fiber-based scaffolds molding by knitting,non-woven and electrospinning.In the future,three-dimensional porous nanofiber-based scaffold with excellent biocompatibility and controllable mechanical property will be the development direction of the tissueengineered heart valve scaffold.

关 键 词：心脏瓣膜 组织工程 纤维基 静电纺丝 纳米纤维 

分 类 号：TS106.67[轻工技术与工程—纺织工程]