芳香醛、苯乙酮和对硝基苯胺一锅法合成Mannich碱  

Synthesis of Mannich Base by One-pot Method with Aromatic Aldehyde,Acetophenone and p-Nitroaniline

作　　者：温俏 李小花[1] 林春秀[1] 徐达[1] 刘春玲[1] 

机构地区：[1]吉林师范大学化学学院,吉林四平136000

出　　处：《广州化工》2015年第1期56-58,共3页GuangZhou Chemical Industry

基　　金：吉林省教育厅"十二五"科学技术研究项目(No.2014157)

摘　　要：在浓盐酸做催化剂的条件下,芳香醛、苯乙酮和对硝基苯胺能够发生Mannich反应,经过提纯得到相应的Mannich碱。用红外光谱对产物的结构进行表征,并研究浓盐酸的使用量、反应温度、反应时间等条件对产率的影响。实验发现在3滴浓盐酸催化下,控温在15-20℃,反应20 h,产率可达60%左右。The Mannich base were synthesized by one- pot method with aromatic aldehyde,acetophenone and p-nitroaniline in concentrated hydrochloric acid. The structural properties of the products were characterized by IR spectrum. The influence of the factors of the quantity of catalyst,the reaction time and temperature on the product yield was systematically studied. It was found that under the conditions of 3 drops of concentrated hydrochloric acid as catalysis,in 15 - 20 ℃ and for 20 h,the production rate can reach 60%.

关 键 词：MANNICH反应 MANNICH碱 芳香醛 苯乙酮 对硝基苯胺 

分 类 号：O622.4[理学—有机化学]