An efficient ionic liquid supported divergent assembly of 3,6-branched glucosamine-containing pentasaccharide  

作　　者：Ze-Shen Gao Sheng Sun Wei Li Qing Ma Qing Li Zhong-Jun Li 

机构地区：[1]The State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University

出　　处：《Chinese Chemical Letters》2014年第12期1525-1530,共6页中国化学快报（英文版）

基　　金：supported by the National Basic Research Program of China(973 Program,No.2012CB822100);the National Key Technology R&D Program "New Drug Innovation" of China (No.2012ZX09502001-001);the National Natural Science Foundation of China(Nos.91213301,21232002)

摘　　要：We utilized the glycosyl acceptor tagging method with ionic liquid support for synthesis of the core segment of Clostridium botulinum C2 toxin ligand through a divergent synthetic strategy without chromatographic purification.The total yield was 57.1% and the reaction was completed in 10 h.The efficient ionic liquid supported glycosylation and purification procedure was applied for the synthesis of branched glucosamine-containing oligosaccharides for the first time,which expanded the scope of ionic liquid supported synthesis of biologically important oligosaccharides.We utilized the glycosyl acceptor tagging method with ionic liquid support for synthesis of the core segment of Clostridium botulinum C2 toxin ligand through a divergent synthetic strategy without chromatographic purification.The total yield was 57.1% and the reaction was completed in 10 h.The efficient ionic liquid supported glycosylation and purification procedure was applied for the synthesis of branched glucosamine-containing oligosaccharides for the first time,which expanded the scope of ionic liquid supported synthesis of biologically important oligosaccharides.

关 键 词：Ionic liquid Oligosaccharide Rapid assembling 

分 类 号：O641.4[理学—物理化学]