Direct N-alkylation of amines with alcohols using AlCl_3 as a Lewis acid  

作　　者：Ya-Qiong Li Yun-Bin Chen Zhi-Zhen Huang 

机构地区：[1]Department of Chemistry,Zhejiang University [2]Zhejiang Jianye Chemical Co.,Ltd. [3]State Key Laboratory of Elemento-Organic Chemistry,Nankai University

出　　处：《Chinese Chemical Letters》2014年第12期1540-1544,共5页中国化学快报（英文版）

基　　金：Financial supports from MOST of China(973 program,No. 2011CB808600);National Natural Science Foundation of China(Nos.21072091 and 21372195);the Low Carbon Fatty Amine Engineering Research Center of Zhejiang Province(No. 2012E10033)

摘　　要：A substitution reaction of amines with alcohols for N-alkylated amines has been developed using inexpensive AlCl3without any ligand or additive.Either aromatic or aliphatic amines and primary or secondary alcohols perform the AlCl3-mediated reaction smoothly to afford various N-alkylated amines in satisfactory yields.A substitution reaction of amines with alcohols for N-alkylated amines has been developed using inexpensive AlCl_3 without any ligand or additive.Either aromatic or aliphatic amines and primary or secondary alcohols perform the AlCl_3-mediated reaction smoothly to afford various N-alkylated amines in satisfactory yields.

关 键 词：Amine Alcohol N-Alkylated amine Lewis acid Synthesis 

分 类 号：O621.25[理学—有机化学]