A novel method for the synthesis of sulfur substituted-cyclopyrophosphate of cADPR analogs  

作　　者：Ren-Min Wu Na Qi Yu-Wen Jia Zhu Guan Liang-Ren Zhang Li-He Zhang Zhen-Jun Yang 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University

出　　处：《Chinese Chemical Letters》2014年第12期1583-1585,共3页中国化学快报（英文版）

基　　金：scientific research funding from the National Natural Science Foundation of China(Nos.21332010,21172010, 21002004)

摘　　要：A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE（P_S^1-cIDPRE） was developed.The key step was the cyclization process which was completed by the sulfur substituted cyclization precursor 1b via the one-pot phosphoramidite strategy.A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE（P_S^1-cIDPRE） was developed.The key step was the cyclization process which was completed by the sulfur substituted cyclization precursor 1b via the one-pot phosphoramidite strategy.

关 键 词：cADPR cIDPRE Phosphoramidite strategy Cyclopyrophosphate 

分 类 号：O629.74[理学—有机化学]