非诺贝特对早期糖尿病肾病患者肾功能的影响  

Effect of Fenofibrate on Renal Function in Patients with Early Diabetic Nephropathy

作　　者：袁江永[1] 周晨光[2] 白桂芝[3] 樊蔚[4] 马雪梅 杜文涛[1] 张俊芳[1] 

机构地区：[1]河北工程大学附属医院心内二科,河北邯郸056001 [2]河北工程大学附属医院血液内科,河北邯郸056001 [3]河北省邯郸市中西医结合医院内科,河北邯郸056001 [4]河北省邯郸市中心医院心内科,河北邯郸056001 [5]河北省邯郸市苏曹社区服务中心,河北邯郸056001

出　　处：《医学临床研究》2014年第12期2315-2317,共3页Journal of Clinical Research

摘　　要：目的探讨非诺贝特对早期糖尿病肾病患者的肾保护作用。方法将84例糖尿病肾病患者随机平均分为对照组和治疗组，对照组进行常规降糖降压治疗，治疗组在此基础上给予非诺贝特治疗，记录比较患者治疗前后血糖、血压、血肌酐（SCr）、血脂和微量白蛋白（mAlb）水平的变化以及核因子-κB （NF-κB）的活性。结果两组患者治疗后空腹血糖（FPG）、餐后2h血糖（2hPG）与治疗前相比较差异均有显著性（P ＜ 0.05）；治疗组患者治疗后 FPG、2hPG与对照组相比较差异无显著性（P ＞0.05）。两组治疗前后及组间 SCr 相相比较差异均无显著性（P ＞0.05）。对照组患者治疗前后血脂各项指标和 mAlb 水平无明显变化（P ＞0.05）；治疗组患者治疗后血脂各项指标和mAlb水平与治疗前比差异具有显著性（P ＜ 0.05）；治疗组与对照组治疗后血脂各项指标和mAlb水平比较差异均有显著性（P ＞0.05）。对照组患者治疗前后 NF-κB的水平无明显变化（P ＞0.05）；而治疗组患者治疗后该水平较治疗前明显下降，且差异有显著性（P ＜ 0.05）；两组患者治疗后 NF-κB水平相比较差异具有显著性（P＜ 0.05）。结论非诺贝特能明显改善早期糖尿病肾病患者血脂和 mAlb 水平，降低 NF-κB P65的活性，从而发挥一定的肾功能保护作用。Obj ective]To explore the renal protective effect of fenofibrate on patients with early diabetic nephropa-thy.[Methods]Totally 84 patients with diabetic nephropathy were randomly divided into control group and treatment group.The control group was treated with conventional blood glucose and pressure-lowering,while the treatment group was treated with fenofibrate based on the treatment of control group.The changes of blood glucose,blood pressure,ser-um creatinine（CCr）,and urine creatinine,blood lipids,microalbumin and the activity of nuclear factor-κB（NF-κB）before and after treatment were recorded and compared.[Results]There were significant differences in fasting blood glucose （FPG）and postprandial 2h blood glucose（2hPG）of two groups between before and after treatment（P〈 0.05）.There was no significant difference in FPG and 2hPG after treatment between treatment group and control group（P 〉0.05）. There was no significant difference in CCr between two groups or before and after treatment（P 〉0.05）.There was no significant difference in blood lipids and microalbumin of control group between before and after treatment（P 〉0.05）. There was significant difference in blood lipids and microalbumin of treatment group between before and after treatment （P〈 0.05）.There was significant difference in blood lipids and microalbumin after treatment between treatment group and control group（P〈 0.05）.There was no significant difference in NF-κB of control group between before and after treatment（P 〉0.05）.Compared with before treatment,NF-κB in treatment group after treatment was obviously de-creased,and there was significant difference（P〈 0.05）.There was significant difference in NF-κB after treatment be-tween two groups（P〈 0.05）.[Conclusion]Fenofibrate can obviously improve blood lipids and microalbumin,and de-crease the activity of NF-κB P6 5 in patients with early diabetic nephropathy.Therefore,it has renal protective effect.

关 键 词：降血脂药/治疗应用 普鲁脂芬/治疗应用 糖尿病肾病/药物疗法 肾功能试验 

分 类 号：R587.24[医药卫生—内分泌]