瑞舒伐他汀对急性心肌梗死模型大鼠MMP-9、TNF-α的影响  

Effect of Rosuvastatin on MMP-9 and TNF-αin Rat Model with Acute Myocardial Infarction

作　　者：龙建平[1] 黄标通[1] 熊卫民[1] 杨彬[1] 

机构地区：[1]中国人民解放军163中心医院胸外科,湖南长沙410003

出　　处：《医学临床研究》2014年第12期2401-2403,共3页Journal of Clinical Research

摘　　要：目的观察瑞舒伐他汀对急性心肌梗死（AMI）大鼠血清基质金属蛋白酶-9（MMP-9）和肿瘤坏死因子-α（TNF-α）的影响,探讨其防治AMI后心室重构的作用机制。方法40只SD大鼠随机选取10只作为假手术组,剩下30只结扎左前降支建立 AMI动物模型,将术后24 h 存活的20只大鼠随机分为模型组和瑞舒伐他汀组,4周后分别检查各组大鼠血流动力学指标和血清 MMP-9、TNF-α含量。结果模型组的平均动脉压（MAP）、左心室内压最大上升速度（＋dp/dtmax ）、左心室内压最大下降速度（-dp/dtmax ）降低,左心室舒张末压（LVEDP）及血清 MMP-9、TNF-α升高,与假手术组比较差异均有显著性（P ＜ 0.01）；瑞舒伐他汀组 MAP、＋dp/dtmax、-dp/dtmax升高,LVEDP、MMP-9、TNF-α降低,与模型组比较差异均有统计学意义（P＜ 0.05或P＜ 0.01）。结论瑞舒伐他汀可减轻 AMI后的心室重构,其作用机制可能与调节血清 MMP-9、TNF-α水平变化有关。Objective]To observe the effect of rosuvastatin on serum matrix metalloproteinase-9（MMP-9）and tumor necrosis factor-alpha（TNF-α）in rats with acute myocardial infarction（AMI）,and to explore the action mechanism for prevention and treatment of ventricular remodeling after AMI.[Methods]Among 40 SD rats,10 rats were randomly selected as the sham group and the remaining 30 rats underwent the ligation of left anterior de-scending branch to establish AMI animal model.After 24h,20 survival rats were randomly divided into model group and the rosuvastatin group.Hemodynamic indexes and serum levels of MMP-9 and TNF-αin rats of each group were examined after 4 weeks.[Results]The MAP,＋ dp/dtmax and -dp/dtmax were decreased,and LVEDP and serum MMP-9 and TNF-αwere increased in model group,and there was significant difference between model group and sham group（P〈 0.01）.In rosuvastatin group,MAP,＋ dp/dtmax and -dp/dtmax were increased,and LVEDP,MMP-9 and TNF-αwere decreased,and there was significant difference between model group and sham group（P〈 0.05 or P〈 0.01）.[Conclusion]Rosuvastatin can reduce ventricular remodeling after AMI.Its mech-anism may be related to the regulation of serum MMP-9 and TNF-α.

关 键 词：降血脂药/药理学 心肌梗死 急性病 基质金属蛋白酶 9 肿瘤坏死因子Α 

分 类 号：R542.22[医药卫生—心血管疾病]