基于静息态fMRI和DTI的大脑性别差异性研究  

Research on the Differences of Brain between the Sexes based on the fMRI and DTI of Resting state

作　　者：宋建太 陶玲[1] 钱志余[1] 俞宙[1] 武江芬 

机构地区：[1]南京航空航天大学自动化学院,江苏南京210016

出　　处：《生物医学工程研究》2014年第4期211-215,220,共6页Journal Of Biomedical Engineering Research

基　　金：国家自然科学基金资助项目(61075107)

摘　　要：本研究从功能和结构两个方面来研究大脑存在的性别差异。利用ICA方法从大脑静息态fMRI数据中分离出大脑默认网络和感觉运动网络,通过双样本t检验来分析男女两性在脑皮层功能上所表现出来的异同;通过构建大脑白质纤维束结构网络,利用网络特征参数来分析男女脑部纤维结构上所存在的差异;通过二者联合技术来探讨两性大脑功能差异和结构差异的关系。结果发现两性大脑功能差异和结构差异在某些脑区有一定的一致性。男女两性大脑生理结构和功能有一定的关联性,两性大脑在功能上的差别可认为与两性在负责相关功能的脑区所具有的差异相关。To study the brain function and structure of gender differces based on the fMRI and DTI technology of resting state. Default network and sensorimotor metwork were isolated from the fMRI data of brain＇s resting state with the ICA method. The similarities and differences on cerebral function between the male and female were analyzed by two sample t-test. The relationship on the brain＇s differences of functional structure between male and female were discused. The differences on the fiber structure of the male and female were analyzed using the ntework characteristic parameters. The results showed that the differences on the brain＇ s function and structure between the male and female had certain consistency in some brain＇s areas. It is concluded that the structure and function of brain between the male and female had certain relevance. It show that the functional differences of brain between the male and female have certain relevance with the difference of functional brain area charged by the male and female respectively.

关 键 词：性别差异 静息态 功能差异 结构差异 

分 类 号：R318[医药卫生—生物医学工程]