利用混合效应线性模型分析甘肃省HIV/AIDS病人HAART后CD_4^+T淋巴细胞的变化  

Observation on the variations of CD_4^+T lymphocytes after highly-active antiretroviral treatment in Gansu Province utilizing linear mixed effects model

作　　者：乔瑞娟[1] 白莉[1] 许亚宁[1] 申希平[2] 杨俊克[1] 杨常敏[1] 王炳涛[1] 石林[1] 

机构地区：[1]甘肃省疾病预防控制中心,兰州730000 [2]兰州大学公共卫生学院,兰州730000

出　　处：《中国艾滋病性病》2014年第12期886-889,共4页Chinese Journal of Aids & STD

基　　金：甘肃省卫生行业科研计划项目(GWGL 2010-32)~~

摘　　要：目的了解甘肃省接受高效抗反转录病毒治疗(HAART)的艾滋病(AIDS)病人CD+4T淋巴细胞(简称CD4细胞)的变化趋势,分析不同性别、年龄、感染途径治疗人群的治疗效果是否存在差异。方法利用SPSS 19.0描述艾滋病病毒(HIV)感染者/AIDS病人(简称HIV/AIDS病人)CD4细胞在治疗后5年内不同时间点上的分布情况,使用混合效应线性模型拟合CD4细胞计数与性别、年龄、感染途径等因素之间的关系。结果选取103例HIV/AIDS病人,男性占67.96%,女性占32.04%;治疗开始年龄以21~50岁为主,占86.41%;感染途径以性接触传播为主,占68.93%。开始治疗前病人CD4细胞中位数为156个/μL,治疗1、2、3、4、5年后,CD4细胞中位数分别为290个/μL、309个/μL、344个/μL、347个/μL、525个/μL。CD4细胞计数与治疗时间和开始治疗时CD4细胞水平正相关;性别和治疗开始年龄没有显著性差异;经男男性行为和血液途径感染的艾滋病病人治疗效果存在统计学差异(P<0.05)。结论甘肃省接受HAART治疗的艾滋病病人在5年内CD4细胞计数有上升趋势,男男性行为感染者的治疗效果较经血液感染者好。Objective To analyze change of CD4^＋ cell counts in HIV/AIDS patients receiving highly active antiretroviral treatment （HAART） in Gansu Province, and analyze if there are diffenent treatment effects between different gender, age and infection routes. Methods CD＋ cell counts at different time points of HIV/AIDS patients treated for 5 years were described by SPSS19.0. Relationship of CD4^＋ cell counts with gender, age and infection routes was analyzed using mixed effects model. Results The study enrolled 103 HIV/AIDS patients. The mate accounted for 67.96% and the female accounted for 32.04%. Most of the patients were at the age of 21-50 years at the start of treatment, accounting for 86.41%. Sex contact was the major transmission route, accounting for 68.93 %. The median value of CD4^＋ cells was 156 eells/uL at baseline. At 1, 2, 3, 4 and 5 years of treatment, it was 290 cells/μL, 309 cells/btL, 344 cells/μL, 347 cells/μL and 525 cells/μL, respectively. Statistical analysis demonstrated that CD4^＋ cell counts were positively correlated with treatment time and level of CD4^＋ cells at baseline. There were no significant differences in gender and age. There were significant differences in curative effects be- tween MSM and those transmitted through contaminated blood（P〈0.05）. Conclusion Within 5 years of HAART, CD; cell counts show an upward trend in Gansu. The curative effect in MSM is better than that in those transmitted through contaminated blood.

关 键 词：艾滋病病毒感染者/艾滋病病人 高效抗反转录病毒治疗 CD_4^+T淋巴细胞计数 线性模型 

分 类 号：R512.91[医药卫生—内科学]