不同剂量胺碘酮联合氯沙坦对阵发性房颤患者复律后窦性心律维持效果的临床研究  

Effect of different doses of amiodarone combined with losartan on maintenance of sinus rhythm of PAF patients

作　　者：李艳[1] 秦立[1] 

机构地区：[1]郑州大学附属郑州中心医院心血管内科,河南郑州450000

出　　处：《中国现代医学杂志》2015年第1期93-95,共3页China Journal of Modern Medicine

摘　　要：目的分析不同剂量胺碘酮联合氯沙坦对阵发性房颤患者复律后的窦性心律维持效果差异。方法选择在该院接受治疗的96例阵发性房颤患者作为研究对象,随机分为小剂量胺碘酮联合氯沙坦治疗的观察组及大剂量胺碘酮联合氯沙坦治疗的对照组,比较两组患者的治疗后窦性心律维持效果、左心室功能及高敏C反应蛋白水平差异。结果观察组患者接受小剂量胺碘酮联合氯沙坦治疗后各个时期的窦性心律维持率均明显高于对照组患者(P<0.05)。观察组患者接受治疗后的Pmax、Pd、LAD值明显低于对照组,LVEF值高于对照组患者(P<0.05)。观察组患者接受治疗后各个时期的血清hs-CRP水平明显低于对照组患者(P<0.05)。结论小剂量胺碘酮联合氯沙坦可以有效提高阵发性房颤复律后的窦性心律维持效果,改善左心房功能,降低高敏C反应蛋白水平。[Objective] To analyze the effect of different doses of amiodarone combined with losartan on mainte- nance of sinus rhythm of PAF patients. [ Methods ] 96 cases of patients with PAF were randomly divided into obser- vation group with low-dose amiodarone combined with losartan and control group with high-dose amiodarone com- bined with losartan. The sinus rhythm maintenance efficacy, left ventricular function and hs-CRP levels in two groups were compared. [ Results ] The sinus rhythm maintain rate in observation group was significantly higher than that in control group（P 〈0.05）. The Pmax, Pd, LAD value in observation group were significantly lower than those in control group, LVEF value in observation group was higher （P 〈0.05）. The hs-CRP serum level in observation group was significantly lower （P 〈0.05）. [ Conclusion] Low-dose amiodarone combined with losartan can effectively im- prove the sinus rhythm after paroxysmal atrial fibrillation cardioerter maintain effect, improve left ventricular func- tion, and reduce levels of hs-CRP.

关 键 词：阵发性房颤 胺碘酮 氯沙坦 

分 类 号：R541.75[医药卫生—心血管疾病]