米索前列醇联合缩宫素预防产后出血的疗效分析  

Misoprostol combined with oxytocin to prevent postpartum hemorrhage

作　　者：唐海燕[1] 王炎[1] 

机构地区：[1]中国人民解放军第181医院妇幼中心,广西桂林541002

出　　处：《中国现代医学杂志》2015年第1期96-97,共2页China Journal of Modern Medicine

摘　　要：目的观察米索前列醇舌下含化联合缩宫素预防产后出血的效果。方法将足月阴道分娩产妇500例,随机分为治疗组和对照组。治疗组250例,在胎儿娩出后予米索前列醇舌下含化,并静脉滴注缩宫素;对照组250例,仅静脉滴注缩宫素。观察并对比两组产后2 h出血量、第三产程时间、产后24 h出血总量及药物不良反应。结果两组产妇在产后2 h出血量、第三产程时间及产后24 h出血总量差异均有统计学意义(P<0.01),治疗组产后出血发生率明显下降(P<0.01),使用米索前列醇后无严重的不良反应。结论米索前列醇联合缩宫素预防阴道分娩产后出血比单用缩宫素效果好,副作用少,值得临床推广使用。[ Objective ] To investigate clinical efficacy of sublingual misoprostol and oxytocin in preventing post- partum hemorrhage. [Methods] 500 cases of maternal vaginal delivery were randomly divided into experimental group and control group. 250 cases of control group injected with oxytocin and the 250 observation group used sub- lingual misoprostol were observed and compared on base of control group. The third stage of labor, 2 h and 24 h postpartum hemorrhage were observed and compared. [Results] The differences of the third stage, 2 h and 24 h postpartum bleeding volume of labor of control and observation group were statistically significant（P 〈0.01）. Postpar- tum hemorrhage of observation group was reduced （P 〈0.01）. [Condusion] Misoprostol combined with oxytocin to prevent postpartum hemorrhage can be better and safety, is worthy of clinical application .

关 键 词：米索前列醇 缩宫素 产后出血 舌下含化 

分 类 号：R714.3[医药卫生—妇产科学]