阿托伐他汀联合阿魏酸钠治疗糖尿病肾病的疗效及对肾间质纤维化指标的影响  

Clinical study of atorvastatin and sodium ferulate diabetic nephropathy patients' renal interstitial fibrosis

作　　者：王爱霞[1] 

机构地区：[1]河南省安阳市人民医院内分泌科,河南安阳455000

出　　处：《中国现代医学杂志》2015年第1期98-101,共4页China Journal of Modern Medicine

摘　　要：目的分析阿托伐他汀联合阿魏酸钠治疗糖尿病肾病的疗效及对肾间质纤维化指标的影响。方法选择在该院接受住院治疗的糖尿病肾病患者作为研究对象,随机分为接受常规降糖治疗的对照组、接受阿托伐他汀联合阿魏酸钠治疗的观察组,比较两组患者的血糖及肾功能水平、血管紧张素及结缔组织生长因子水平及血清炎性因子水平差异。结果观察组患者接受治疗后的空腹血糖、尿素氮、血肌酐和尿蛋白排泄率水平均明显低于对照组(P<0.05)。观察组患者接受治疗后的血清及尿液血管紧张素Ⅱ及结缔组织生长因子水平均明显低于对照组(P<0.05)。观察组患者接受治疗后的血清hs-CRP、TNF-α和IL-6水平均明显低于对照组(P<0.05)。结论阿托伐他汀联合阿魏酸钠治疗可以有效改善糖尿病肾病患者的血糖及肾功能、延缓肾间质纤维化和降低全身炎症状态。[ Objective ] To analyze the effect of atorvastatin and sodium ferulate on diabetic nephropathy patients renal interstitial fibrosis. [ Methods ] 96 cases of patients with diabetic nephropathy were randomly divided into con- trol group received routine hypoglycemic therapy, observation group received atorvastatin and sodium ferulate thera- py. The blood glucose level and renal function, Ang Ⅱ and CTGF levels, serum inflammatory cytokines levels in two groups were compared. [Results] The levels of GLU, BUN, Cr and UAER in observation group were significantly lower than that in control group （P 〈0.05）. The serum and urine Ang Ⅱ and CTGF levels in observation group were significantly lower（P 〈0.05）. The levels of serum hs-CRP, TNF-α, IL-6 in observation group were significantly lower than that in control group（P 〈0.05）. [Conclusion] Atorvastatin and sodium ferulate therapy could effectively reduce blood glucose level in diabetic nephropathy patients, improve renal function, delay renal interstitial fibrosis, reduce systemic inflammatory state.

关 键 词：糖尿病肾病 肾间质纤维化 阿魏酸钠 阿托伐他汀 

分 类 号：R587.2[医药卫生—内分泌]