TNFa拮抗剂诱发结核1例报道并文献复习  

TNFa Antagonist-induced Tuberculosis: a Case Report and Literature Review

作　　者：陈雪融[1] 吴桂辉 唐晓燕[1] 鄢秀英[1] 

机构地区：[1]四川大学华西医院呼吸科,四川成都610041 [2]成都市传染病院结核科,四川成都610000

出　　处：《现代预防医学》2015年第2期376-378,共3页Modern Preventive Medicine

基　　金：国家自然科学基金(81202375)

摘　　要：目的探讨1例TNFa拮抗剂诱发的结核病例的发病机制、诊断、治疗方法及人文启示。方法回顾性分析1例TNFa拮抗剂诱发的结核病例临床资料并复习相关文献。结果患者表现为发热、咳嗽和淋巴结肿大,活检证实诊断为胸椎结核、肺结核、淋巴结结核。经医患积极沟通和多学科协作诊治,予手术及抗结核治疗后病情好转。结论TNFa拮抗剂诱发的结核病例值得引起重视,治疗中积极的沟通及多学科协作是关键。Objective This study was to investigate the pathogenesis, diagnosis, treatment and humanistic enlightenment of TNFa antagonist-induced tuberculosis. Methods The clinical data of a case of tuberculosis triggered by TNFa antagonist were retrospectively analyzed, and literature review about this case was conducted. Results A male patient of 14 years old presented fever, cough,expectoration and enlargement of lymph node. The disease was diagnosed as thoracic spinal tuberculosis, pulmonary tuberculosis and lymphoid tuberculosis by biopsy. After active communications between the doctor and the patient, and multidisciplinary consultation, the patients received surgery and anti-tuberculosis therapy. His condition was improved after the treatment. Conclusion This case of tuberculosis triggered by TNFa antagonist is clinically important. Active communication between doctors and patients and multidisciplinary cooperation are important for the successful treatments.

关 键 词：TNFa拮抗剂 结核病例 文献复习 

分 类 号：R52[医药卫生—内科学]