131例活血化瘀中药注射剂不良反应报告分析  

Analysis of 131 Cases of Adverse Drug Reactions Reports Induced by Traditional Chinese Medicine Injection of Promoting Blood Circulation for Removing Blood Stasis

作　　者：赖剑锋[1] 张洁[1] 陈春枚[1] 

机构地区：[1]福建医科大学附属龙岩第一医院,福建龙岩364000

出　　处：《药物流行病学杂志》2015年第1期40-43,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：目的：探讨活血化瘀中药注射剂不良反应发生的特点，为其安全评价与合理用药提供参考。方法：对我院2010年1月～2014年2月收集的135例活血化瘀中药注射剂ADR进行统计分析。结果：131例ADR报告中，舒血宁注射液病例数最多（29例）；多在用药30min内发生（107例，81．68％）；患者原患疾病多为神经系统性疾病（48．85％）、循环系统疾病（28．00％）；不良反应涉及多个器官或系统，以全身性损害最多（42例，17．87％）。结论：临床应重视对活血化瘀中药注射剂ADR的监测和报告，临床药师参与临床治疗工作，促进该类药品临床安全、合理用药。Objective ：To investigate the features and general patterns of adverse drug reactions （ADRs） induced by Traditional Chinese Medicine injection of promoting blood circulation for removing blood stasis （TCMIP）, and provide reference for safety evaluation and rational drug use. Methods：Through retrospective research technique, 131 ADR cases who were induced by TCMIP collected in our hospital from Jan. 2010 to Feb. 2014 were analyzed statistically. Results： A- mong 131 ADR reports, 29 cases which had the largest number were related to Shuxuening injection. Most of ADR cases occurred within 30 minutes after using stasis removing agent （ 107 cases ,81.68% ）. The diseases of patients mostly were the nervous system（48.85% ） and the circulatory system（28.00% ）. TCMIP may induce multiple organs or systematic ADRs. The incidence of Body as a whole-general disorders was 17.87 % （42 cases）. Conclusion：ADRs induced by TCMIP monito- ring and reporting should be strengthened in clinic. Meanwhile, clinical pharmacists should participate in clinical medicine treatment to promote rational and safety use of TCMIP.

关 键 词：活血化瘀中药注射剂 药品不良反应 报告 

分 类 号：R286[医药卫生—中药学]