局灶性脑缺血损伤后低氧诱导因子1α促神经元凋亡的作用机制  

Study on the Mechanism of Hypoxia-Inducible Factor-1α in Promoting Neuron Apoptosis after Focal Cerebral Ischemic Injury

作　　者：汪卫东[1] 张洪峰[1] 王乐[1] 王朝宗[1] 

机构地区：[1]邯郸市中心医院药学部,河北邯郸056001

出　　处：《医学综述》2015年第1期25-27,共3页Medical Recapitulate

摘　　要：大脑是对缺氧非常敏感的器官,氧浓度降低可以诱导低氧诱导因子1α(HIF-1α)的快速大量表达,尤其在缺血半暗带,及时挽救该部位的神经元是减轻缺血性损伤的关键。HIF-1α是一种核转录因子,能够诱导胱天蛋白酶、p53、诱导型一氧化氮合酶、Bcl-2等促凋亡基因的转录表达、促进氧自由基的产生以及影响血脑屏障的通透性。近年来,许多研究阐述了HIF-1α在局灶性脑缺血损伤的病理生理机制中,尤其是促神经元凋亡方面,扮演着非常重要的角色。The brain is very sensitive to hypoxia,the lower concentration of oxygen would induce massive and rapid expression of hypoxia-inducible factor-1α （HIF-1α）,especially in the ischemic penumbra.While saving the neuron in ischemic penumbra timely is the key to reduce ischemic injury.HIF-1α is a kind of nuclear transcription factor that can induce the transcription of caspases,p53,inducible nitric oxide synthase,Bcl-2 and other prp-apoptotic genes,and promote generation of oxygen free radicals and affect the permeability of blood-brain barrier.In recent years,many studies have illustrated that HIF-1 α plays a pivotal role in the pathophysiological mechanism of focal cerebral ischemia injury,especially in promoting the injured neuron apoptosis.Here is to make a review of the pro-apoptosis mechanism of HIF-1α after focal cerebral ischemic injury.

关 键 词：局灶性脑缺血 低氧诱导因子1Α 神经元 凋亡 

分 类 号：R87[医药卫生—运动医学]