吡罗昔康在纳米Fe_3O_4-石墨烯复合修饰玻碳电极上的电化学行为及电分析研究  

Electrochemical behavior of Piroxicam on a glassy carbon electrode modified with nano-Fe_3O_4-reduced graphene oxide and its electrochemical determination

作　　者：张青春[1] 张志华 张瑞[1] 彭娟[1] 高作宁[1] 

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021 [2]宁夏康亚药业有限公司,宁夏银川750002

出　　处：《化学研究与应用》2015年第1期28-33,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(21265014)资助

摘　　要：采用纳米Fe3 O4粒子（ nano-Fe3 O4）和石墨烯（ Reduced Graphene Oxide,RGO）制备了nano-Fe3 O4-RGO复合材料修饰玻碳电极（nano-Fe3O4-RGO/GCE）,采用循环伏安法（cyclic voltammetry,CV）,方波伏安法（square wave voltammetry,SWV）,计时电流法（ chronoamperometry,CA）,计时库仑法（ chronocoulometry,CC）研究了吡罗昔康（ Piroxicam,PC）在此复合修饰电极上的电化学行为及电化学动力学性质。实验结果表明,与GCE相比, nano-Fe3 O4-RGO/GCE对PC的电化学氧化作用有显著的促进作用,其氧化峰电流显著增加；对各种实验条件进行了优化,测得峰电流Ipa与PC浓度在2．0×10^-6～2．0×10^-4 mol·L^-1范围内呈良好的线性关系,检出限（S/N=3）为5．3×10^-7 mol·L^-1,加标回收率为100．0%～104．0%。该方法快速,灵敏,并将nano-Fe3O4-RGO/GCE用于市售吡罗昔康片剂的测定,结果符合定量测定要求。The nano-Fe3 O4 and reduced graphene oxide （ RGO ） composite modified glassy carbon electrode （ nano-Fe3 O4-RGO/GCE）was fabricated,the electrochemical behavior and electrochemical properties of the anti-inflammatory drug Piroxicam（PC）at the nano-Fe3 O4-RGO/GCE,RGO/GCE and GCE were investigated by electrochemical impedance spectroscopy（ EIS） ,cyclic volta-mmetry（CV）,square wave voltammetry（SWV）,chronoamperometry（CA）and chronocoulometry（CC）. The experimental results showed that the electrochemical response of PC is much greater on the nano-Fe3 O4-RGO/GCE than on the bare glassy carbon elec-trode. the oxidation peak currents increased linearly range from 2. 0×10^-6 to 2. 0×10^-4 mol·L^-1 with the detection limit（S/N=3）of 5. 3×10^-7 mol·L^-1 and the recoverage is in the range of 100. 0% ～104. 0%. Compared with other modified electrode,the nano-Fe3 O4-graphene modified glassy carbon electrode was convenient to prepare,and it exhibited a satisfactory accuracy and precision, and long-term stability,and could be used in the determination of piroxicam in pharmaceutical.

关 键 词：吡罗昔康 nano-Fe3 O4 石墨烯 玻碳修饰电极 电催化氧化 电分析方法 

分 类 号：O657.1[理学—分析化学]