Modification of biomaterials surface by mimetic cell membrane to improve biocompatibility  

作　　者：Lei ZHOU Guo-Xin TAN Cheng-Yun NING 

机构地区：[1]School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China [2]College of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China

出　　处：《Frontiers of Materials Science》2014年第4期325-331,共7页材料学前沿（英文版）

基　　金：The authors gratefully acknowledge the financial support of the National Basic Research Program of China （Grant No. 2012CB619100） and the National Natural Science Foundation of China （Grant Nos. 51372087, 51232002, and 51072055）.

摘　　要：Modification of biomaterials surface by mimetic cell membrane for improving biocompatibility, to imitate the excellent biological and physiological proper- ties of the natural cell membrane, is an important research area in materials science. Numerous studies have been attempted to construct a mimetic cell membrane biointer- face composed of phosphorylcholine （PC）-containing polymers or other phospholipid analogues on biomaterials surface. PC-containing biointerfaces show outstanding characteristics, especially in biological aspects such as blood compatibility and antifouling property. In this mini-review, the strategies of membrane mimetic modification of biomaterials and their antifouling applications are summarized.Modification of biomaterials surface by mimetic cell membrane for improving biocompatibility, to imitate the excellent biological and physiological proper- ties of the natural cell membrane, is an important research area in materials science. Numerous studies have been attempted to construct a mimetic cell membrane biointer- face composed of phosphorylcholine （PC）-containing polymers or other phospholipid analogues on biomaterials surface. PC-containing biointerfaces show outstanding characteristics, especially in biological aspects such as blood compatibility and antifouling property. In this mini-review, the strategies of membrane mimetic modification of biomaterials and their antifouling applications are summarized.

关 键 词：mimetic cell membrane phosphorylcholine （PC） BIOCOMPATIBILITY SURFACEMODIFICATION biomaterial 

分 类 号：TQ174.75[化学工程—陶瓷工业] TB303[化学工程—硅酸盐工业]