非血红素铁、锰配合物催化烯烃不对称环氧化反应研究进展  

Recent progress in asymmetric epoxidation of olefins catalyzed by non-heme iron, manganese complexes

作　　者：苗成霞[1,2] 夏春谷[1,2] 孙伟[1,2] 

机构地区：[1]羰基合成与选择氧化国家重点实验室 [2]中国科学院兰州化学物理研究所,兰州730000

出　　处：《中国科学：化学》2014年第12期1865-1875,共11页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(21103207,21133011)的资助

摘　　要：手性环氧化物是重要的有机反应中间体.金属氧化酶催化的氧化反应通常具有高效、高选择性、反应条件温和和绿色的特点,模拟其中的非血红素铁加氧酶设计合成一系列手性四氮铁锰配合物催化烯烃不对称环氧化反应成为获得高产率、高对映选择性的手性环氧化物的一个重要方法.本文综述了近年来非血红素手性四氮铁锰配合物催化烯烃不对称环氧化反应的研究进展及相应的机理研究.Optically active epoxides are regarded as important intermediates in organic reactions. Metallooxy- genases-catalyzed oxidations often exhibit high efficiency as well as selectivity, and operate under mild conditions through inherently green processes. Asymmetric epoxidation of olefins catalyzed by a series of iron or manganese complexes with chiral tetradentate nitrogen ligands to mimic non-heme iron dioxygenase has become an important method for obtaining chiral epoxides with high yields and high enantioselectivities. Recent progress in asymmetric epoxidation of olefins catalyzed by iron or manganese complexes with tetradentate nitrogen ligands and the corresponding mechanisms are described.

关 键 词：烯烃 不对称环氧化 非血红素 四氮铁锰配合物 

分 类 号：O643.32[理学—物理化学]