影响早期糖尿病肾病尿微量白蛋白相关因素的临床研究  

Clinical Study on Effect of Related Factors of Microalbuminuria in Early Stage of Diabetic Nephropathy

作　　者：吴大梅[1] 陈静[1] 刘继涛[2] 李文[1] 

机构地区：[1]贵阳中医学院基础医学院,贵阳550025 [2]贵阳中医学院研究生部,贵阳550025

出　　处：《世界科学技术-中医药现代化》2014年第11期2411-2414,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：贵州省科技厅贵阳中医学院联合基金项目(2010LKZ7016):早期糖尿病肾病防治的KY3H健康保障服务的理论及临床研究;负责人:陈静;贵州省中医药管理局中医药/民族医药科学技术研究课题(QZYY2010-09):运用中医"治未病"理论防治早期DN的KY3H健康保障服务的临床研究;负责人:陈静

摘　　要：目的:探讨糖尿病肾病(DN)早期患者尿微量白蛋白(MAU)的相关影响因素。方法:通过流行病学调查,收集早期DN患者证候资料,用Logistic回归分析早期DN患者MAU(应变量)与影响因素(自变量)之间的关系,探讨DN早期患者MAU的影响因素。结果:流行病学的研究结果显示:生活方式喜动、性格易急躁、饮酒、年龄高、病程长、痰湿体质、气郁体质、舌质紫或暗、脉细数、阴虚燥热证、气阴两虚证、寒湿证与DN早期发病有密切关系。结论:早期DN患者MAU"20-52μg·m L-1"共114例,危险因素有性格易急躁、气郁体质、舌质紫或暗、阴虚燥热证、气阴两虚证、寒湿证;保护因素为生活方式喜动。早期DN患者MAU"53-199μg·m L-1"共95例,危险因素是饮酒、年龄高、病程长、痰湿体质、脉细数。This study was aimed to explore factors related to microalbuminuria of early stage of diabetic nephropathy （DN）. Through epidemiologic survey, syndrome data of patients with early stage of DN were collected. The analysis was made on relationship between MAU （strain） of early stage of DN patients and the influencing factors （variable） with logistic regression analysis. The influencing factors were investigated in the early stage of DN patients in MAU. The epidemiological study showed a close relationship between factors such as active living style, easy irritability, drinking, old age, long disease course, phlegm and dampness body constitution, qi-stagnation body constitution, purple or dark tongue, thin and rapid pulse, yin deficiency and heat pattern, qi-yin deficiency pattern, cold and dampness pattern with the incidence of early stage of DN. It was concluded that there were 114 cases of early stage of DN with MAU of 20-52 μg·mL^-1. The risk factors contained easy irritability, qi-stagnation body constitution, purple or dark tongue, yin deficiency and heat pattern, qi-yin deficiency pattern, as well as cold and dampness pattern. The protective factor contained active living style. There were 95 cases of early stage of DN with MAU of 53-199 μg·mL^-1. The risk factors contained drinking, old age, long disease course, phlegm and dampness body constitution, as well as thin and rapid pulse.

关 键 词：糖尿病肾病早期 尿微量白蛋白 LOGISTIC回归 影响因素 

分 类 号：R587.1[医药卫生—内分泌]