PTH、BUN及CRe联合检测对早期肾功能衰竭的诊断价值  

Clinical Significance of Joint Detection of Parathyroid Hormone Urea Nitrogen, Creatinine in the Diagnosis of Early Renal Failure

作　　者：张来[1] 赵卫红[2] 周瑛[1] 邱君思[1] 阎丰[1] 黄海华[1] 宋丹[1] 

机构地区：[1]南京医科大学附属无锡第二医院肾内科,江苏无锡214000 [2]南京医科大学第一附属医院肾内科,江苏南京210029

出　　处：《现代生物医学进展》2014年第35期6883-6885,共3页Progress in Modern Biomedicine

基　　金：2013年度南京医科大学科技发展项目(2013NJMU186);国家自然科学基金项目(81070588)

摘　　要：目的:探讨甲状旁腺激素、尿素氮及肌酐联合检测在肾功能衰竭患者早期诊断中的临床意义。方法:选取2012年1月-2013年8月在我院接受治疗的80例肾功能衰竭患者作为研究对象,另选同期体检正常人40例为对照组,选用我院全自动化学分析仪器及电化学发光免疫分析测量仪器检测患者血清中甲状胖腺激素、尿素氮及肌酐水平。结果:与对照组患者比较,观察组患者血清样本中甲状旁腺激素水平、尿素氮水平与肌酐水平呈显著增高趋势,有统计学意义(P<0.05)。肾功能衰竭患者在其代偿期血清内三项水平呈显著增高趋势,而在氮质血症期间,血清内三项要素水平升高现象更为显著,而在尿毒症期间,对比氮质血症期间同样有其上升的表现,突出表现为显著的增高态势。结论:在临床诊断中,可将血清样本中甲状旁腺激素水平作为判定其肾功能衰竭严重程度的关键指标。Objective： To study the clinical significance and correlation of joint detection of parathyroid hormone, urea nitrogen and creatinine in the diagnosis of early renal failure patients. Methods： 80 patients with renal failure from January 2012 to August 2013 in our hospital were selected as the research object. Using the automatic chemical analysis instrument and the electrochemical luminescence immunoassay measuring instrument, the level of parathyroid hormone in serum, urea nitrogen and creatinine was detected. Results：Compared with the control group patients, the levels of parathyroid hormone, urea nitrogen and creatinine in serum samples significantly increased in observation group with obvious statistical significance（P〈0.05）. In the compensatory phase of renal failure, the three levels in serum significantly increased, and during the period of azotemia, the elevated levels were more pronounced, and during the period of uremia, the level of parathyroid hormone, urea nitrogen and creatinine also had a significant rise in comparison to the period of azotemia.Conclusion： In clinical diagnosis, the serum level of parathyroid hormone can be a key indicator of the severity of renal failure.

关 键 词：早期诊断 肾功能衰竭 尿素氮 甲状旁腺激素 肌酐 

分 类 号：R692.5[医药卫生—泌尿科学]