系统性红斑狼疮并发肺动脉高压患者的临床特点及预后分析  

Characteristics and prognosis of pulmonary arterial hypertension in patients with systemic lupus erythematosus

作　　者：任义乐[1] 丁翔[1] 张璐[2] 

机构地区：[1]南京医科大学连云港临床医学院风湿免疫科,江苏连云港222002 [2]苏州大学附属第三医院风湿免疫科,江苏常州213003

出　　处：《今日健康》2014年第8期29-30,共2页

摘　　要：目的：分析系统性红斑狼疮（SLE）并发肺动脉高压（PAH）患者的临床特点及预后。方法：收集1999年至2012年江苏省15所医院521例SLE患者首次住院临床资料，将其分为PAH组与非PAH组，采用χ2检验、t检验比较两组患者临床特点，应用LogRank检验、χ2检验比较两组患者预后。结果：79例（15．2％）SLE患者在首次住院时心脏彩超检查发现有PAH。PAH组血液异常发生率及血沉水平（73．4％、65．0mm／1h）明显高于非PAH组（61．8％、54．5mm／1h）（P〈0．05）。PAH组生存预后显著差于非PAH组（P〈0．01），其首次住院后1年、5年生存率明显低于非PAH组（88．6％、68．2．0％vs．96．1％、93．3％，均P〈0．01）。结论：PAH在SLE病程早期阶段已较为常见，易同时并发血液系统受累，体内炎症水平较高，预后较差。Objective： To analyze the clinical characteristics and prognosis of pulmonary arterial hypertension （PAH） in patients with systemic lupus erythematosus （SLE）. Methods： Medical records of 521 SLE patients from 15 hospitals at the first admission from 1999 to 2012 in JiangSu province were reviewed. They were divided into two groups with or without PAH. Clinical characteristics between two groups were compared by χ2 test and t test. Prognosis between them was analyzed throuth Log Rank test and χ2 test.Results： 79 （15.2%） SLE patients with PAH were found by echocardiogram tests during the first hospitalization. SLE patients with PAH showed higher ratio of hematologic disorder （73.4%） and higher levels of erythrocyte sedimentation rate （ESPy） （65.0mm/h） compared to those without PAH （61.8%,54.5 mm/1h）. The prognosis of SLE patients with PAH was worse than those without PAH（P〈0.01）. The survival rate of SLE patients with PAH was lower at 1 or 5 year after the first hospitalization than those without PAH （88：6%, 68.2.0% vs. 96.1%, 93.3%, both P〈0.01）.Conclusion： PAH may be often seen in the early stage of SLE. In these patients, hematologic disorders and over-activation of inflammation are common and their prognosis are bad.

关 键 词：系统性红斑狼疮 肺动脉高压 临床特点 预后 

分 类 号：R593.241[医药卫生—内科学]