系统性红斑狼疮患者合并骨质疏松症的危险因素分析  

Risk factors of osteoporosis in patients with systemic lupus erythematosus

作　　者：孙占娟[1] 丁翔[1] 

机构地区：[1]连云港市第一人民医院风湿免疫科,江苏连云港222002

出　　处：《今日健康》2014年第8期32-32,370,共2页

基　　金：连云港市卫生局课题.编号：1207

摘　　要：目的探讨系统性红斑狼疮（SLE）患者发生骨质疏松症（OP）的危险因素。方法收集2011年1月至2014年8月在我科住院的50例女性SLE患者临床资料，分为OP组与非OP组，采用t检验、χ2检验或确切概率法比较两组患者临床特点。结果16例（32％）SLE患者合并OP。OP组患者病程、糖皮质激素应用超过1年及狼疮肾炎发生率显著高于非OP组（4．6yrs，75．0％，68．8％vs2．4vrS，35．3％，23．5％，P〈0．05），SLE患者糖皮质激素应用超过1年或发生狼疮肾炎时合并OP的相对危险度为5．5和7．2（P〈0．05），OP组患者血清25-OH维生素D3水平显著低于非OP组（12．0VS22．2ng／ml，P〈0．05）。结论SLE患者OP的发生率较高，长时间应用糖皮质激素和狼疮肾炎是发生OP的高危因素，应及时监测其血清25-OH维生素D3及骨密度水平并给予规范治疗。Objective To investigate the risk factors of osteoporosis （OP） in patients with systemic lupus erythematosus （SLE）. Methods Clinical data of 50 female SLE patients from January 2011 to August 2014 in our hospital were collected. These patients were derided into two groups with or without OP. The clinical features between two groups were compared by t test, χ 2 test or Fisher＇s exact test.Results 16 （32%） SLE patients were diagnozed with OP. The disease duration, the ratio of glucocorticoid application more than 1 year and the rate of lupus nephritis in OP group were significantly longer or higher than those in non-OP group （4.6yrs, 75.0%, 68.8% VS 2.4yrs, 35.3%, 23.5%,P〈0.05）. The relative risk of OP among SLE patients with glucocorticoid application more than 1 year or lupus nephritis are 5.5 times and 7.2 times （P〈 0.05）. The serum 25-OH vitamin D3 level in OP group was significantly lower than that in non- OP group （12.0VS 22.2ng/ml , P 〈 0.05）. Conclusion The incidence rate of OP in SLE patients was high and the long use of glucocorticoid and lupus nephritis were its risk factors. Serum 25-OH vitamin D3 and bone mineral density should be timely monitored, and standard treatment should be administered.

关 键 词：系统性红斑狼疮 骨质疏松症 危险因素 

分 类 号：R593.24[医药卫生—内科学]