富血小板血浆治疗坐骨结节滑囊炎  

Platelet-rich plasma for treatment of ischiogluteal bursitis

作　　者：沈梓维 林子洪[1] 郑秋坚[1] 王良泽[1] 叶圣龙[1] 李盛[1] 钱思浓 

机构地区：[1]广东省医学科学院(广东省人民医院),广东省广州市510080

出　　处：《中国组织工程研究》2014年第47期7689-7696,共8页Chinese Journal of Tissue Engineering Research

摘　　要：背景:坐骨结节滑囊炎被认识长久,但其治疗手段仍保留在40年前的封闭及手术等方法。目的:分析富血小板血浆注射治疗坐骨结节滑囊炎的疗效。方法:收集15例坐骨结节滑囊炎患者资料。所有患者双侧同时接受富血小板血浆(n=10例,共20侧)或封闭(n=5例,共10侧)注射治疗。随访6-14个月,采用目测类比评分法、治疗满意度评分及复发率进行评估,比较这两种治疗方法在各观察时间点的评分,评估治疗效果。结果与结论:在目测类比评分方面,富血小板血浆组和封闭组综合各时间点的结果比较差异无显著性意义(F=0.219,P=0.643);分别在各个时间点两组间比较,富血小板血浆注射的疼痛评分在短期内(治疗后1周内)高于封闭注射,但长期随访的疼痛评分低于封闭组。在总体满意度、疗效和不良反应评分方面,富血小板血浆注射在短期内(尤其是治疗后1周)的评分不如封闭注射,但持久的长期评分却高于封闭注射。在方便性评分方面,两者差异无统计学意义。末次随访富血小板血浆注射治疗的复发率较封闭注射低。分析结果说明对于坐骨结节滑囊炎的治疗,富血小板血浆注射和封闭注射均可缓解疼痛,封闭注射的短期疗效更好,尤其是在治疗后1周内,但其长期疗效不佳,而富血小板血浆注射起效缓和,但疗效持久、复发率更低。BACKGROUND：Ischiogluteal bursitis has been recognized for a long time, but its treatment stil limits to local blocking injection and surgery methods that were developed 40 years ago. OBJECTIVE：To observe the efficacy of platelet-rich plasma on ischiogluteal bursitis. METHODS：Data of 15 patients with ischiogluteal bursitis were colected. Al the patients with ischiogluteal bursitis were treated with bilateral platelet-rich plasma （n=10） or local blocking injection （n=5）. Patients’ outcomes were assessed by visual analogue scale, the Treatment Satisfaction Questionnaire for Medication （TSQM） Version II and recurrence rate. The folow-up time was from 6 to 14 months. RESULTS AND CONCLUSION： There was no statistical difference in visual analogue scale score between the platelet-rich plasma group and local blocking group （F=0.219,P=0.643）, but the score of visual analogue scale in the platelet-rich plasma group was higher during short-term folow-up （within 1 week after treatment）, but lower in the long-term folow-up. In the aspects of overal satisfaction score, clinical effectiveness and side effects, the platelet-rich plasma group was inferior to the local blocking group at short-term folow-up, especialy at 1 week after treatment; however, these scores became better in the platelet-rich plasma group than the local blocking group during the long-term folow-up period. In addition, no statistical difference in the convenience score wasfound between the two groups. At the last folow-up, the recurrence rate in the platelet-rich plasma group was lower than that in the local blocking group. Both the platelet-rich plasma and local blocking injection can significantly reduce the pain of patients with ischiogluteal bursitis. Local blocking injection has better short-term effectiveness. Platelet-rich plasma injection works moderately, but its effectiveness can last for longer time, and the recurrence rate is lower.

关 键 词：生物材料 材料相容性 富血小板血浆 坐骨结节滑囊炎 封闭治疗 

分 类 号：R318[医药卫生—生物医学工程]