建立反映心脏内部各腔室结构的数字化三维模型  

Digital three-dimensional model reconstruction of the cardiac cavity

作　　者：陈中中[1] 张建飞[1] 苏智剑[1] 连登伟 杨亚茹[1] 朱慧玉[2] 

机构地区：[1]郑州大学机械工程学院,河南省郑州市450001 [2] 河南省生产力促进中心,河南省郑州市450001

出　　处：《中国组织工程研究》2014年第49期7967-7973,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:心脏内部各腔室精细结构的数字化三维模型,不仅能够加强对心脏生理的认识,还能为心脏电生理仿真与心内膜电生理标测导航的研究提供重要的基础医学数据。目的:建立符合心腔实际解剖结构的三维数据,建立反映心脏内部各腔室结构的数字化三维模型。方法:在MATLAB软件环境下完成图像分割,首先对医学人体断层数据集中心脏切片图像进行自动配准,再运用聚类法根据图像的颜色特征对图像中各组织与成分进行分类,随后经区域生长法处理实现心腔及相关连通区域的图像分割与提取。所得图像导入专用医学图像处理软件,完成心腔三维模型重建。结果和结论:所提出的方法能够重建出较为精细的心腔结构三维模型。此模型中左右心房、心室结构明晰,能清楚地观察到主动脉、上腔静脉等血管,三尖瓣与二尖瓣等微细结构也有所体现。结果说明,重建的三维模型能够准确地反映出人体心腔解剖学结构特征,为心脏电生理方面的仿真和标测研究提供基础的医学数据支持。BACKGROUND：Digital three-dimensional model which can reflect the fine structure of the chambers inside heart not only enhances the understanding of cardiac physiology, but also provides basic medical data for the study of cardiac electrophysiology simulation and endocardial electrophysiological mapping navigation. OBJECTIVE：To construct the digital three-dimensional model of cardiac cavity from sectional data and in conformity with the actual anatomical structure. METHODS：Image segmentation was accomplished in MATLAB environment. Firstly, registration of human cardiac cavity slice dataset was realized. Secondly, classifying each composition was achieved by clustering method according to color characteristics of the image. Then, both cardiac cavity and related connected region was distinguished by region growing method. At last, the processed image was reconstructed through dedicated medical processing software into three-dimensional model of the cardiac cavity. RESULTS AND CONCLUSION：The proposed method could reconstruct quite exquisite three-dimensional model of the cardiac cavity. In models, left and right atrial and ventricular structure was clear. Aorta and superior vena cava were visible. Three tricuspid and mitral valve were also observed. Results indicated that reconstructed model can reflect the anatomical characteristics of cardiac cavity accurately, and provide basic medical data for＆amp;nbsp;the study on electrophysiological simulation and endocardial electric mapping.

关 键 词：实验动物 组织工程 心腔 解剖结构 三维重建 断层数据 器官和组织 图像配准 图像分割 聚类法 区域生长法 图像熵 

分 类 号：R318[医药卫生—生物医学工程]