贻贝粘性蛋白组成、作用机理与应用  

The Research Progress on Mussel Adhesive Proteins

作　　者：朱曜曜 丁海兵[1] 孙承君[2] 

机构地区：[1]中国海洋大学,山东青岛266100 [2]国家海洋局第一海洋研究所,山东青岛266061

出　　处：《海洋科学进展》2014年第4期560-570,共11页Advances in Marine Science

基　　金：国家自然科学基金--贻贝闭壳肌-壳界面的粘结机理和仿生研究(31100567);国家海洋局基础科研业务专项资金--生物与无机底物界面粘结机理研究及仿生防污材料的表征(2011T10);2012人社部留学归国人员科技择优项目--有机-无机界面(贻贝闭壳肌-壳界面)粘结

摘　　要：从贻贝足丝的结构和组成特征开始,全面总结了到目前为止所发现的贻贝足丝内部和表面层的结构特点以及相关重要组成蛋白的种类和理化特性,着重讨论了在贻贝足丝粘附中起重要作用的足丝斑块部分的粘性蛋白组成、结构、分布特征以及相互作用。同时,也讨论了贻贝粘附机理以及DOPA(3,4-二羟基苯丙氨酸)在实践中的重要应用,探讨了DOPA的作用及其衍生物在粘胶剂、密封剂、涂料、生物防污等领域,特别是生物医学中的应用和前景。Starting from the structural and compositional characteristics of mussel byssus, we thoroughly summarized the up-to-date research on the structure and function of byssal thread, including the byssus inner structure and outside coating, the main components of the byssus and the various properties of related proteins. More emphasis was put on the plaque proteins because byssus plaque plays the most important role in the adhesion of the mussel. The composition, distribution, and the various interactions among these adhesive proteins in the plaque were reviewed. We also discussed the mechanism of mussel adhesion and the important role of DOPA （3,4-dihydroxyphenylalanine）. The function of DOPA, its application and the potentials of its derivatives in adhesive, sealant, paint, anti-fouling, and biomedical materials were also discussed.

关 键 词：贻贝 粘性蛋白 DOPA 生物污损 生物防污 

分 类 号：X834[环境科学与工程—环境工程]