针刺加药物治疗对急性脑梗死患者血浆溶血磷脂酸的影响  

Effects of Acupuncture and“Tongxinluo”Capsule on Plasma Lysophosphatidic Acid Level in Patients with Acute Cerebral Infarction

作　　者：刘南海[1] 黄晓峰[1] 田克瑶 李熳[3] 陈伟[1] 朱长东[2] 黄旭华[1] 冯李长[1] 彭文杰[1] 

机构地区：[1]赣南医学院第一附属医院神经内科,赣州341000 [2]赣南医学院第二附属医院神经内科,信丰341600 [3]华中科技大学同济医学院神经生物学系,武汉430030

出　　处：《针刺研究》2014年第6期487-490,511,共5页Acupuncture Research

基　　金：江西省科技厅科技计划项目(No.20123BBG 70209)

摘　　要：目的:探讨针刺加中药对急性缺血性脑血管疾病的治疗效果及作用机制。方法:急性脑梗死患者随机分为针刺组、通心络组、针刺加通心络组和常规治疗组,各40例。针刺穴位以内关、三阴交、水沟为主,病灶对侧手足阳明经穴为配穴,每次30min,每次选手足阳明经2对腧穴给予电针,每日1次,共治疗20d;通心络胶囊每次服4粒,3次/d,连续服20d;常规治疗包括抗血小板聚集及改善血液循环。以定磷法测定4组患者治疗前后血浆溶血磷脂酸(LPA)含量,以神经功能缺损评分为标准分别判定4组患者的疗效。结果:4组患者治疗后与治疗前比较,血浆LPA含量均明显降低(P<0.01);针刺加通心络组低于其它组(P<0.01);疗效比较,针刺加通心络组患者治愈+显著进步的百分率显著高于其它3组(P<0.01)。结论:针刺治疗能促进脑梗死患者缺损神经功能恢复,并有效降低脑梗死患者血浆LPA含量,且与通心络胶囊具有协同作用。Objective To observe the effect of acupuncture of Neiguan （PC 6）, Sanyinjiao （SP 6）, etc. on plasma ly- sophosphatidic acid （LPA） level in patients with acute cerebral infarction （ACI） so as to study its mechanism underlying improve- ment of ACI. Methods A total of 160 patients with ACI were randomly divided into four groups： medication （Aspirin and Panax Notoginseng Saponins for improving blood circulation）, acupuncture, Tongxinluo, and acupuncture ＋ Tongxinluo groups, with 40 cases being in each group. Plasma LPA content was measured using biochemical method, and the therapeutic effects of the 4 groups were assessed by neurologic deficit score which were evaluated using the modified standards of the 4＊＂ Session of Chinese National Oerebrovascular Conference issued in 1995. Results Following the treatment, plasma LPA levels and neurological de- ficit scores were significantly decreased in the medication, acupuncture, Tongxinluo and acupuncture＋ Tongxinluo groups in com- parison with pre-treatment in each group （P-〈0.01）, and LPA level and neurological deficit score of the acupuncture ＋ Tongxinluo group were significantly lower than those of the other three groups （P^0.01）. Of the four 40 cases in the medication, acupunc- ture, Tongxinluo and acupuncture＋ Tongxinluo groups, 6, 7, 7 and 12 patients were basically cured, 9, 8, 9 and 18 experienced marked improvement in their symptoms, 14, 16, 15 and 6 were improved, 6, 5, 4 and 2 were invalid, 5, 4, 5 and 2 got wors- ened, with the effective rates（basically cured＋ improvement） being 37.5%, 37.5%, 40.0% and 75.0%, respectively. The therapeutic effect of the acupuncture＋ Tongxinluo group was significantly superior to those of the other three groups （P〈0.01）.Conclusion Acupuncture can accelerate the recovery of neurological function and ameliorate clinical symptoms in ACI patients, which may be related to its effect in lowering plasma PLA. The therapeutic effect of acupuncture ＋ Tongxinluo is relatively bette

关 键 词：脑梗死 针刺治疗 通心络胶囊 血浆溶血磷脂酸 神经功能 

分 类 号：R246.2[医药卫生—针灸推拿学]