双能X线骨密度仪精密度和准确度的研究  

Study of the precision and accuracy of dual-energy X-ray bone densitometry

作　　者：金超岭 王猛[1] 李红磊[1] 刘鸿娥[1] 颜珏[1] 

机构地区：[1]中日友好医院核医学科,北京100029

出　　处：《中国骨质疏松杂志》2014年第12期1425-1427,共3页Chinese Journal of Osteoporosis

摘　　要：目的通过测量长、短期精密度和短期准确度对双能X线吸收法(dual-energy X-ray absorptiometry,DXA)骨密度仪进行质量控制。方法 1长期精密度:对质量保证(Quality Assurance,QA)模块连续1年的测试数据进行统计分析,分别计算其高、中、低骨密度、均值骨密度、骨矿盐含量、投影面积的变异系数(coefficient of variation,CV);2短期精密度:取连续25天的QA模块测试数据,计算高、中、低骨密度平均值和标准差(standard deviation,SD),制作Shewhart质控图。另外选取30名志愿者,分别测量L1-4椎体,双侧股骨颈、大粗隆、Ward's三角、全髋关节的骨密度(bone mineral density,BMD)值,计算均方根变异系数(root mean square of the CV,RMS-CV);3短期准确度:取连续25天的QA模块测试数据,计算高、中、低骨密度的准确度。结果 1长期精密度:QA模块测量高、中、低骨密度、均值骨密度、骨矿盐含量、投影面积的CV分别为0.37%、0.37%、0.41%、0.43%、0.47%、0.12%;2短期精密度:连续25天QA模块测试数据均符合Shewhart法则;30例受试者L1-4椎体,双侧股骨颈、大粗隆、Ward's三角、全髋关节各测量部位的RMS-CV分别为1.3%、0.8%、0.9%、1.2%、1.3%、1.5%、1.6%、0.6%、0.6%;3短期准确度:连续25天QA模块测试数据的高、中、低骨密度的准确度分别为-0.07%、0.10%、0.60%。结论进行长、短期精密度和准确度测试能反映双能X线吸收骨密度仪的一致性和可靠性,可有效提高骨质疏松的流行病学研究、诊断、治疗、药物试验研究的可信度。Objective To study the long-term and short-term precision and short-term accuracy of quality assurance （ QA） in using dual-energy X-ray absorptiometry （ DXA ） .Methods 1 ） Long-term precision： the consecutive 1-year data from QA phantom were statistical analyzed, and the high-, middle-, and low-bone mineral density （ BMD ） , mean BMD, bone mineral content, and projected area of coefficient of variation （CV） were calculated.2）Short-term precision：the data of QA phantom of 25 consecutive days were collected.The mean and standard deviation （ SD） of the high-, middle-, and low-BMD were calculated. The Shewhart chart was created.BMD of the L1-4 vertebral body, bilateral femoral neck, the greater trochanter, ward triangle, and the total hip joint of 30 volunteers was measured.The root mean square of the CV （RMS-CV） was calculated.3） Short-term accuracy：the data of QA phantom of 25 consecutive days were collected.The accuracy of the high-, middle-, and low-BMD were calculated.Results 1） Long-term precision：the CV of high-, middle-, low-BMD, mean BMD, bone mineral content, and projected area was 0.37%, 0.37%, 0.41%, 0.43%, 0.47%, and 0.12%, respectively.2） Short-term precision：the data of QA phantom for 25 consecutive days met the Shewhart rule.The RMS-CV value of L1-4 vertebral body, the bilateral femoral neck, the the bilateral greater trochanter, the the bilateral Ward triangle, and the total hip joint of 30 volunteers was 1.3%, 0.8%, 0.9%, 1.2%, 1.3%, 1.5%, 1.6%, 0.6%, and 0.6%, respectively.3） Short-term accuracy：the accuracy of the data of high-, middle -, low-BMD yielded by scanning QA phantom for 25 consecutive days was -0.07%, 0.10%, and 0.60%, respectively.Conclusion The consistency and reliability of DXA can be reflected by the long-term and short-term precision and accuracy trail.It can effectively raise the credibility of the epidemiological investigation, diagnosis, treatment, and drug testing of osteoporosis.

关 键 词：双能X线吸收法 质量控制 长期精密度 短期精密度 短期准确度 

分 类 号：R814.4[医药卫生—影像医学与核医学]