冰冻血小板低温损伤及防护机制的研究进展  

Research Advance on Frozen Injury and Protective Mechanisms of Cryopreservated Platelets——Review

作　　者：易晓阳[1] 王艳[1] 韩颖[1] 

机构地区：[1]军事医学科学院野战输血研究所,北京100850

出　　处：《中国实验血液学杂志》2014年第6期1761-1765,共5页Journal of Experimental Hematology

摘　　要：血小板作为人体血液中的重要组分,在生理性止血中起着非常重要的作用。血小板的输注主要用于特发性血小板减少性紫癜、放化疗病人的血小板减少以及其他原因导致的出血性血小板减少症。室温保存时间(5 d)限制了血小板的临床应用,导致血小板的废弃率不断升高,因此延长血小板的保存时间对血小板的临床应用意义重大。目前-80℃冻存血小板是一种较为理想的长期保存方法,本文就血小板冰冻保存过程中损伤及对其防护机制的研究进展作一综述。Platelets are important component in the blood which play vital role in physiological hemostasis. In clinic, platelets are usually transfused to patients suffered from idiopathic thrombocytopenic purpura, thrombocytopenia after chemotherapy and radiotherapy, or hemorrhagic thrombocytopenia caused by other reasons. Storage time for platelet concentrates is limited to five days at room temperature, leading to an increasing number of scrap rate, therefore the prolonging the storage time is important for clinical application. Storage at - 80 ℃ is an ideal long-term cryopreservation method for platelet concentrates. In this article, platelets cryopreservafion, the mechanism of frozen injury and the protective mechanisms of platelets were reviewed.

关 键 词：血小板 冰冻保存 损伤机制 防护机制 

分 类 号：R331.143[医药卫生—人体生理学] R318.52[医药卫生—基础医学]