EB病毒与其相关淋巴瘤的研究进展  

Research Progress on Epstein-Barr Virus and Its Related Lymphoma——Review

作　　者：王滕滕[1] 袁田[1] 张翼鷟[1] 

机构地区：[1]天津医科大学肿瘤医院血液科,国家肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室,天津300060

出　　处：《中国实验血液学杂志》2014年第6期1775-1779,共5页Journal of Experimental Hematology

基　　金：天津市应用基础与前沿技术研究计划(BJCYBJC22800)

摘　　要：EB病毒(Epstein-Barr virus,EBV)属于r-DNA疱疹病毒科,是最早被发现与人类肿瘤相关的病毒。大量研究发现,EBV的感染与多种淋巴瘤的发生有关,如霍奇金淋巴瘤、伯基特淋巴瘤、NK/T细胞淋巴瘤、HIV相关的淋巴瘤和弥漫大B细胞淋巴瘤等。近年来研究表明,EBV潜伏感染的基因表达产物对淋巴瘤的发生发展起到促进作用,并为EBV相关淋巴瘤的治疗提供了依据。现就EBV在几种常见淋巴瘤中的作用机制及治疗的研究进展做如下综述。Epstein-Barr virus（EBV）belongs to r-DNA herpes virus family and the first discovered virus associated with human tumors.Numerous studies have found that EBV infection is related to the occurrence of a variety of lymphomassuch as Hodgkin＇ s lymphomaBurkitt＇ s lymphomaNK /T-cell lymphomaHIV-related lymphoma and diffuse large B-cell lymphoma.Recent studies indicated that the gene expression products of EBV latent infections play an important role in the lymphomaand these findings provide the theoretical basis for the treatment of EBV-related lymphoma.This review mainly discusses the progress in the mechanism and the therapy of EBV-related lymphoma.

关 键 词：EB病毒 EB病毒感染 淋巴瘤 

分 类 号：R373[医药卫生—病原生物学] R733.1[医药卫生—基础医学]