新型肠道病毒A71、A90和B87型血清流行病学调查  

Seroprevalence of the Newer Enterovirus Types A71,A90 and B87 in Healthy Individuals in Shandong Province,China

作　　者：刘晓林[1] 王素婷[1] 林小娟[1] 陶泽新[1] 王海岩[1] 宋立志[1] 张丽[1] 徐爱强[1] 

机构地区：[1]山东省疾病预防控制中心,山东省传染病预防控制重点实验室,山东大学预防医学研究院

出　　处：《病毒学报》2014年第6期614-618,共5页Chinese Journal of Virology

基　　金：山东省2012年科学技术发展计划医药卫生项目(2012YD18044)

摘　　要：为了解山东省人群中新型肠道病毒（EV）A71、A90和B87型抗体水平及自然感染状况,以便为制订相关防控措施提供依据,本研究利用2010年在山东省烟台市各年龄组健康人群中采集到的血清样本400份,采用中和试验检测EV-A71、A90和B87抗体水平,并对检测结果进行统计学分析。结果表明,调查人群EV-A71、A90和B87型中和抗体阳性率分别为46.0%、8.8%和47.0%,抗体几何平均滴度（GMT）分别为1：5.20、1：1.49和1：4.02。EV-A71抗体阳性率在＂1岁~＂年龄组儿童中最低,EV-B87在＂7月~＂年龄组儿童中最低,之后逐渐升高,5岁以上儿童抗体阳性率较为一致。EV-A90各年龄组人群抗体阳性率较为一致。由此推测,EV-A71母传抗体水平出生后迅速下降,感染可能主要发生于3~7岁的幼儿园及低年级儿童。健康人群,尤其是儿童中EV-B87抗体阳性率较高,人群中可能存在一定的免疫屏障。人群中EV-A90抗体阳性率较低,需要对其加强监测。This study aimed to investigate antibody levels of the newer human enteroviruses（EV）A71,A90,and B87 in the population of Shandong Province,and provide a scientific basis for the development of prevention and control measures.In this study,serum specimens were collected from 400 individuals living in Yantai city,Shandong Province in 2010.EV-A71,A90,and B87 antibodies were detected using neutralization tests,and the results were analyzed by statistical methods.It was found that the positive neutralizing antibody rates of EV-A71,A90 and B87in the population were 46.0%,8.8%,and 47.0%,respectively.Their geometric mean titers（GMT）were 1∶5.20,1∶1.49,and 1∶4.02,respectively.Positive antibody rates for EV-A71 and EV-B87 were lowest in the 1~ yr and 7~ mo age groups,respectively.Positive rates increased gradually with age,and become consistent in the population aged 〉5years.Positive antibody rates of EV-A90 were consistent across all age groups.Maternal antibody levels of EVA71 declined rapidly after birth,and the increase in seroprevalence among 3~7years old children implied that most EV-A71 infections occurred in preschool and early elementary school children.High positive antibody rates of EV-B87 in healthy individuals,especially children,implied that there may be an immune barrier within the general population.The population monitoring of EV-A90 should be strengthened,as its positive antibody rate is low.

关 键 词：新型肠道病毒 血清流行病学 中和抗体 阳性率 滴度 

分 类 号：R373.2[医药卫生—病原生物学]