血浆氨基末端脑钠肽前体与急性心肌梗死相关性临床研究  

The correlation study between plasma N-terminal pro-B-type natriuretic peptide and acute myocardial infarction

作　　者：贾明理 李昌 夏豪[3] 曾彬[3] 

机构地区：[1]阳新县人民医院心血管内科,湖北省黄石市435200 [2]湖北省中山医院心血管内科 [3]武汉大学人民医院心血管内科

出　　处：《中国心血管病研究》2015年第1期20-23,共4页Chinese Journal of Cardiovascular Research

基　　金：国家自然科学基金（项目编号：81270184）

摘　　要：目的 探讨氨基末端脑钠肽前体（NT-proBNP）对急性心肌梗死（AMI）诊断的临床意义.方法 选取2012年5月至2014年10月在我院心内科住院诊断为急性心肌梗死患者188例（AMI组）及诊断为非急性心肌梗死患者114例（对照组）,统计患者基本临床资料及入院24h内实验室检查结果,分析NT-proBNP与AMI的相关性.结果 AMI组与对照组相比,在年龄、性别、高血压史、吸烟史、饮酒史、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）上未见统计学差异,糖尿病史、NT-proBNP、肌酸激酶同工酶（CK-MB）、肌红蛋白（MYO）、超敏肌钙蛋白Ⅰ（ultra-TnⅠ）、丙氨酸氨基转氨酶（ALT）、天门冬氨酸氨基转移酶（AST）、血糖（Glu）比较,差异有统计学意义.NT-proBNP与ultra-TnⅠ之间存在良好的相关关系（r2=0.746,r=0.864,P＜0.01）.ROC曲线显示,AUCM-proBNP=0.952,Cut-offNT-proBNP=246.82 pg/ml,诊断急性冠脉综合征灵敏度为87.9％,特异度为81.3％.结论 氨基末端脑钠肽前体对急性心肌梗死的早期诊断具有较好的诊断价值.Objective To investigate the correlation between plasma N-terminal pro-B-type natriuretic peptide and acute myocardial infarction. Methods 188 patients diagnosed with acute coronary syndrome and 114 patients diagnosed with no acute coronary syndrome were studied basic clinical characters. Results Age, sex, hypertension, smoking, drinking, TC, TG, HDL, LDL have no statistical significance between acute myocardial infarction group and control group. Diabetes mellitus, NT-proBNP, CK-MB, MYO, ultra-TnI, ALT, AST, Glu have statistical significance between acute myocardial infarction group and control group. The levels of NT-proBNP and ultra-TnI had a positive correlation （r^2=0.746, r=0.864, P〈0.01 ）. ROC curve analysis showed NT-proBNP was valuable for the diagnosis of acute coronary syndrome （P〈0.01）. The predictive sensitivity of acute coronary syndrome was 87.9% and the specificity was 81.3% when NT-proBNP level was 246.82 pg/ml. Conclusion NT-proBNP has good diagnostic value on the early diagnosis of acute myocardial infarction.

关 键 词：氨基末端脑钠肽前体 急性心肌梗死 相关性 

分 类 号：R542.22[医药卫生—心血管疾病]