单纯性肥胖患者铁代谢指标的检测及分析  

Changes and analysis of the parameters of iron metabolism in obese adults

作　　者：徐淑静[1] 孙雪[2] 时立新[1] 张巧[1] 彭年春[1] 

机构地区：[1]贵阳医学院附属医院内分泌科,贵州贵阳550004 [2]湖北医药学院附属东风总医院内分泌科,湖北十堰431017

出　　处：《中国现代医学杂志》2014年第35期67-69,共3页China Journal of Modern Medicine

基　　金：贵州省科技厅社会发展科技攻关计划项目(No:黔科合LG字[2011]017号)

摘　　要：目的检测单纯性肥胖患者血清铁代谢相关指标,探讨其与铁代谢的关系。方法单纯性肥胖患者43例(肥胖组)、体检健康者43名(对照组)。测定所有受试者血清铁蛋白(SF)、铁调素(hepcidin)及可溶性转铁蛋白受体(s Tf R)水平。结果两组之间SF、铁调素及s Tf R水平差异无统计学意义(P>0.05)。在肥胖组及对照组中血清铁蛋白与铁调素均正相关(r=0.337,P<0.05;r=0.424,P<0.01),与可溶性转铁蛋白受体均负相关(r=-0.438,P<0.01;r=-0.521,P<0.01)。结论轻度单纯性肥胖者铁代谢指标无明显改变。[Objective] To determine the levels of parameters of iron metabolism in obese subjects and explore the relationship between iron metabolism and obese. [Methods] Forty-three obese subjects （obese group） and 43 healthy subjects（control group）were enrolled in this study. Serum ferritin （SF）, hepcidin, soluble transferrin receptor （sTfR） were determined. [Results] SF and hepcidin and sTfR levels between the two groups were not different （P〉0.05）. In both groups, SF were positively related with hepcidin （r=0.337, P〈 0.05; r=0.424, P〈0.01）, but negatively related with sTfR （r=-0.438, P〈0.01; r=-0.521, P〈0.01）. [Conclusion] The results showed that the parameters of iron metabolism in mildly obese adults did not change significantly.

关 键 词：铁蛋白 铁调素 可溶性转铁蛋白受体 单纯性肥胖 

分 类 号：R589.2[医药卫生—内分泌]