PON1基因Q192R位点多态性与氯吡格雷抵抗的临床研究  

Clinical relationship between PON1 gene Q192R polymorphism and clopidogrel resistance

作　　者：黄勤[1] 尹秋林[1] 胡耀[1] 

机构地区：[1]江西省人民医院心内二科,南昌330006

出　　处：《临床心血管病杂志》2014年第12期1053-1055,共3页Journal of Clinical Cardiology

摘　　要：目的:探索PON1基因Q192R单核苷酸多态性(SNP)与经皮冠状动脉介入治疗术(PCI)患者发生氯吡格雷抵抗(CR)的相关关系。方法:采用病例-对照研究法,入选160例患者,采用光学比浊法测定残余血小板聚集率(RPA),差值<10%定义为CR,据此将入选患者分为CR组和无CR组,采用测序法测定PON1基因Q192RSNP的基因型及等位基因分布频率。结果:PON1基因Q192R多态位点在两组间基因型分布频率皆符合Hardy-Weinberg平衡定律,PON1基因Q192RSNP与患者CR的发生无相关关系。结论:PON1基因Q192R SNP位点与PCI术后患者CR的发生无关。Objective：To explore the relationship between PON1 gene Q192R single nucleotide polymorphisms （SNP） and clopidogrel resistance （CR） in percutaneous coronary intervention patients. Method： A case-control method was employed in present study, A taotai of 160 patients with coronary heart diseases was enrolled. The residual platelet aggregation rate （RPA）was detected by optical nephelometry, and ARPA〈10% was defined as CR. Accordingly, all the enrolled 160 patients were then divided into CR group and non-CR （NCR） group. PCR and Sanger sequencing were executed to determine the genotypes and the allele frequencies of PON1 gene Q192. Result： The genotype frequencies in Q192R of PON1 gene conformed well to the Hardy-Weinberg equilibrium in both CR group and NCR group. No significant difference in genotype and allele frequency existed between CR group and NCR group. Conclusion： it is considered that no correlation exists between PON1 gene Q192R polymorohism and cloDidogrel resistance in patients post PCI.

关 键 词：氯吡格雷抵抗 PON1 基因多态性 

分 类 号：R514.4[医药卫生—内科学]