氢生理盐水治疗大鼠继发性心肌损伤的相关研究  

Correlation analysis of hydrogen-rich saline treating for secondary myocardial injury in rats

作　　者：韩斐斐[1] 韩力[2] 

机构地区：[1]徐州医学院临床学院内科学与诊断学教研室,江苏徐州221004 [2]华中科技大学同济医学院

出　　处：《临床心血管病杂志》2014年第12期1112-1114,共3页Journal of Clinical Cardiology

摘　　要：目的:应用氢生理盐水治疗大鼠继发性心肌损伤,观察其疗效并探讨其机制。方法:建立大鼠中度颅脑损伤模型,实验动物随机分为对照组、损伤+生理盐水组、损伤+含氢生理盐水组,于脑损伤后24h断头处死大鼠,收集血清,用全自动生化分析仪测定血清心肌肌酸激酶同工酶(CK-MB)的变化;利用分光光度比色法检测心肌组织中丙二醛(MDA)的水平。结果:大鼠颅脑损伤后血清CK-MB升高,心肌组织内MDA水平升高,而损伤+含氢生理盐水组大鼠的血清CK-MB较损伤+生理盐水组明显降低,且心肌组织内MDA水平亦明显下降。结论:腹腔内注射含氢生理盐水能够通过抑制氧化损伤,降低大鼠颅脑损伤后血清CK-MB及心肌组织内MDA水平,改善大鼠颅脑损伤后继发性的心肌损伤。Objective：To investigate the effects of hydrogen-rich saline on secondary myocardial damange in rats and its mechanisms. Method.. Models of moderate traumatic brain injury in rat were established. Rats were randomized into normal control group, FPlq-saline group and FPI＋hydrogen-rich saline group. Rats were decapitated at 24 hours after brain injury, creatine kinase myocardial isoenzyme （CK-MB） and propionate dialdehyde （MDA） levels of myocardial tissue were measured and statistically analyzed. Resdt： The levels of CK-MB and MDA were all increased after FPI, and the levels of CK-MB and MDA in FPI＋ hydrogen-rich saline group were significantly lower than that in FPI＋ saline group （P〈0.05）. Conclusion： With injected intraperitoneally, hydrogen-rich saline could reduce the level of CK-MB and MDA and show the protective effects on secondary myocardial damange after traumatic brain injury.

关 键 词：继发性心肌损伤 颅脑损伤 氢生理盐水 

分 类 号：R542.2[医药卫生—心血管疾病]