双波长红外激光诱发痛觉刺激研究  

Research of Pain Stimulus Induced by Dual-Wavelength Infrared Laser System

作　　者：穆志明[1] 杨基春[1] 董晓曦[1] 胡勇[1] 金文东[1] 李迎新[1] 

机构地区：[1]中国医学科学院生物医学工程研究所,天津300192

出　　处：《中国激光》2015年第1期156-161,共6页Chinese Journal of Lasers

摘　　要：搭建红外波段双波长(1940 nm和980 nm)激光诱发痛觉刺激系统,探索基线温度控制、激光吸收导热涂层、致痛区域控制对痛觉刺激效果的影响。利用热电偶测温模块实时监测基线温度控制及涂抹20%氧合血红蛋白溶液时离体猪皮皮肤表面温度的变化;利用滤光片实现致痛区域控制。利用1940 nm激光模块实现了40℃基线温度控制,结合980 nm脉冲激光模块完成了联合痛觉刺激实验;皮肤表面涂抹20%氧合血红蛋白溶液时温降时间(110 ms)远低于空白对照(1.2 s)和风冷散热(341 ms),可提升痛觉信号质量;列举了三种不同尺寸滤光片下的温度场分布情况,证明了致痛区域的可控性。双波长红外激光诱发痛觉系统提出的三种技术对痛觉刺激效果有较好的促进作用,证明了这种痛觉刺激模式的可行性和可信性。A 1940 nm and 980 nm laser pain stimulus system is built to explore the effect of baseline temperature control, oxyhemoglobin solution and laser irradiation area control on laser pain stimulus. With pig skin, a thermocouple module is used to monitor the change of the skin temperature under baseline temperature control and 20% oxyhemoglobin solution; the shape and size of the light is controlled with the help of filters. By using the 1940 nm laser control of baseline temperature of 40 ℃ is realized and joint pain stimulus experiment is carried out with the help of the 980 nm laser. Surface temperature drop time under the condition of 20% oxyhemoglobin solution （110 ms） is much lower than the blank control （1.2 s） and air cooling heat dissipation （341 ms）, proving that this is an ideal method to improve pain signal quality. Temperature field distribution with three different filters is listed, proving that the shape and size of the pain stimulus is controllable. The three technologies in the dual-wavelength pain stimulus mode mentioned above can improve the result of the laser pain stimulus and prove the feasibility and credibility of this system.

关 键 词：激光光学 痛觉 激光诱发电位 基线温度 氧合血红蛋白 致痛区域 

分 类 号：R318.51[医药卫生—生物医学工程]