利谷隆致雄性仔鼠睾酮分泌的影响机制  

Linuron male seed induced by the effect of testosterone secretion mechanisms

作　　者：韩华[1] 李岩[2] 

机构地区：[1]遵义市第一人民医院营养科,贵州遵义563003 [2]遵义医学院公共卫生学院,贵州遵义563003

出　　处：《医药前沿》2015年第1期169-171,共3页Journal of Frontiers of Medicine

基　　金：贵州省教育厅重点项目基金10.00（黔教科2008033号）,贵州省科技厅基金4.0[黔科合J字（2007）2125号],贵州省长特殊人才基金7.0[黔省专合字（2007）54号]

摘　　要：目的：采用抗雄激素类除草剂利谷隆染毒受孕的SD大鼠，观察利谷隆对雄性仔鼠睾酮分泌的影响。方法：孕鼠50只，在孕13—18d时连续6d利谷隆灌胃染毒，对照组给予等量花生油，利用电镜检测、ELISA和免疫组化的方法，分别检测不同染毒剂量组，影响睾酮生成的细胞器、关键酶及睾酮的分泌量的变化。结果：不同染毒剂量组睾酮生成的细胞器受损伤、生成睾酮的关键酶被抑制、睾酮的分泌量依次降低。 结论：利谷隆通过对雄性仔鼠生成睾酮细胞器的毒性损害及其关键酶的抑制，导致睾酮的分泌量降低，最终阻碍了雄性仔鼠性的分化和性发育。Objective Androgen herbicide resistant linuron infected pregnant SD rats, observe the linuron effects on male young rat testosterone secretion. Methods Pregnant rats 50, in six consecutive at 13 - 18 d d linuron lavage canister, the control group given amount of peanut oil, using electron microscopy （sem） test, ELISA and immunohistochemical method, testing different infected dose groups, respectively, produced testosterone organelles, key enzymes and the quantity of the secretion of testosterone. Results Different infected dose testosterone generated organelles, damaged, generate the key enzyme of testosterone were inhibited, the secretion of testosterone in turn down. Conclusions Linuron by male young rats produce testosterone organelles, toxic damage and key enzyme inhibition leads to the secretion of testosterone decreased, eventually hindered the male rats sexual differentiation and development

关 键 词：利谷隆 睾酮 雄性仔鼠 

分 类 号：R994.6[医药卫生—毒理学]