蠕虫感染与过敏性和自身免疫性疾病  

Effect of helminth infection on allergic and autoimmune diseases

作　　者：杨维平[1] 田芳[1] 胡雪莉[1] 

机构地区：[1]扬州大学医学院病原生物学与免疫学教研室,扬州225001

出　　处：《中国人兽共患病学报》2014年第12期1252-1256,共5页Chinese Journal of Zoonoses

基　　金：国家自然科学基金项目(No.81101265/H1906)~~

摘　　要：许多研究发现蠕虫感染后虫源性分子诱导免疫细胞形成免疫调节网络,介导免疫抑制,从而抑制过敏性和自身免疫性疾病。寄生虫可以通过诱导免疫调节细胞活化和产生细胞因子发挥抑制效应,从而影响其他免疫相关疾病。然而,蠕虫感染与免疫相关疾病之间的调节机制尚无明确的结论。一些蠕虫感染可以保护和控制过敏性疾病,而另一些蠕虫却加剧疾病的免疫病理损害。Many studies show that helminth-derived molecules can induce immunoregulatory cells to form immune net work-mediated immune, thereby inhibiting allergic and autoimmune diseases. Helminth parasites can induce immune cell activa tion and produce cytokine. And parasites play an inhibitory effect to affect other immune related diseases. However, the associ ation between helminths infections and immune related diseases does not always have an unequivocal outcome. While some hel minths infections protect against allergic diseases, other helminth can exacerbate this immunopathology.

关 键 词：蠕虫感染 过敏性疾病 自身免疫性疾病 调节性T细胞 调节性B细胞 

分 类 号：R383[医药卫生—医学寄生虫学]